Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

被引：31
|
作者：
Fernandez, Gabriela A. [1 ]
Vela Gurovic, Maria S. [1 ]
Olivera, Nelda L.
Chopa, Alicia B. [1 ]
Silbestri, Gustavo F. [1 ]
机构：
[1] Univ Natl Sur, Dept Quim, INQUISUR, Bahia Blanca, Buenos Aires, Argentina
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 135卷
关键词：
Water-soluble Au(I); N-heterocyclic carbene; Antibacterial; ANTIMICROBIAL ACTIVITY; SILVER; AGENTS; RESISTANCE; TOXICITY; AG(I);
D O I：
10.1016/j.jinorgbio.2014.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropyl-phenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coll. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：54 / 57
页数：4
相关论文
共 50 条
  • [31] Antimicrobial Properties of Some Bis(Iminoacenaphthene (BIAN)-Supported N-Heterocyclic Carbene Complexes of Silver and Gold
    Butorac, Rachel R.
    Al-Deyab, Salem S.
    Cowley, Alan H.
    MOLECULES, 2011, 16 (03) : 2285 - 2292
  • [32] Synthesis, structures, and antimalarial activities of some silver(I), gold(I) and gold(III) complexes involving N-heterocyclic carbene ligands
    Hemmert, Catherine
    Fabie, Aymeric
    Fabre, Aude
    Benoit-Vical, Francoise
    Gornitzka, Heinz
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 60 : 64 - 75
  • [33] Amine-fnctionalized silver and gold N-heterocyclic carbene complexes: Synthesis, characterization and antitumor properties
    Kizrak, Umran
    Ciftci, Osman
    Ozdemir, Ilknur
    Gurbuz, Nevin
    Dusunceli, Serpil Demir
    Kaloglu, Murat
    Mansour, Lamjed
    Zaghrouba, Fethi
    Hamdi, Naceur
    Ozdemir, Ismail
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2019, 882 : 26 - 32
  • [34] Silver(I), Gold(I) and Gold(III)-N-Heterocyclic carbene complexes of naphthyl substituted annelated ligand: Synthesis, structure and cytotoxicity
    Samanta, Tapastaru
    Munda, Rudra Narayan
    Roymahapatra, Gourisankar
    Nandy, Abhishek
    Das Saha, Krishna
    Al-Deyab, Salem S.
    Dinda, Joydev
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2015, 791 : 183 - 191
  • [35] Synthesis of N-heterocyclic carbene-based silver complexes and their antimicrobial properties against bacteria and fungi
    Kaloglu, Murat
    Kaloglu, Nazan
    Gunal, Selami
    Ozdemir, Ismail
    JOURNAL OF COORDINATION CHEMISTRY, 2022, 74 (17-20) : 3031 - 3047
  • [36] N-Heterocyclic Carbene Gold(I) and Copper(I) Complexes in C-H Bond Activation
    Gaillard, Sylvain
    Cazin, Catherine S. J.
    Nolan, Steven P.
    ACCOUNTS OF CHEMICAL RESEARCH, 2012, 45 (06) : 778 - 787
  • [37] Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity
    Ozdemir, Ilknur
    Temelli, Nazan
    Gunal, Selami
    Demir, Serpil
    MOLECULES, 2010, 15 (04): : 2203 - 2210
  • [38] Mechanochemical synthesis of Cu(i)-N-heterocyclic carbene complexes
    Pisano, Gianmarco
    Cazin, Catherine S. J.
    GREEN CHEMISTRY, 2020, 22 (16) : 5253 - 5256
  • [39] Cytotoxic Gold(I) N-heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors
    Rubbiani, Riccardo
    Salassa, Luca
    de Almeida, Andreia
    Casini, Angela
    Ott, Ingo
    CHEMMEDCHEM, 2014, 9 (06) : 1205 - 1210
  • [40] Synthesis of hydroxyl-functionalized N-heterocyclic carbene gold(I) complexes and peptide conjugates
    Diehl, Tobias
    Krause, Melanie T. S.
    Ueberlein, Sven
    Becker, Stefanie
    Trommer, Aline
    Schnakenburg, Gregor
    Engeser, Marianne
    DALTON TRANSACTIONS, 2017, 46 (09) : 2988 - 2997
12345