Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

被引：31
|
作者：
Fernandez, Gabriela A. [1 ]
Vela Gurovic, Maria S. [1 ]
Olivera, Nelda L.
Chopa, Alicia B. [1 ]
Silbestri, Gustavo F. [1 ]
机构：
[1] Univ Natl Sur, Dept Quim, INQUISUR, Bahia Blanca, Buenos Aires, Argentina
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 135卷
关键词：
Water-soluble Au(I); N-heterocyclic carbene; Antibacterial; ANTIMICROBIAL ACTIVITY; SILVER; AGENTS; RESISTANCE; TOXICITY; AG(I);
D O I：
10.1016/j.jinorgbio.2014.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropyl-phenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coll. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：54 / 57
页数：4
相关论文
共 50 条
  • [21] Protonated water-soluble N-heterocyclic carbene ruthenium(II) complexes: Synthesis, cytotoxic and DNA binding properties and molecular docking study
    Akkoc, Mitat
    Balcioglu, Sevgi
    Gurses, Canbolat
    Tok, Tugba Taskin
    Ates, Burhan
    Yasar, Sedat
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2018, 869 : 67 - 74
  • [22] Synthesis, characterization, in vitro antibacterial, and anticancer studies of Ag(I)-N-heterocyclic carbene (NHC) complexes
    Ulu, Oznur Dogan
    Kurucay, Ali
    Ates, Burhan
    Ozdemir, Ismail
    CHEMICAL PAPERS, 2023, 77 (01) : 423 - 435
  • [23] Anti-trypanosomal activity of cationic N-heterocyclic carbene gold(I) complexes
    Winter, Isabel
    Lockhauserbaeumer, Julia
    Lallinger-Kube, Gertrud
    Schobert, Rainer
    Ersfeld, Klaus
    Biersack, Bernhard
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2017, 214 : 112 - 120
  • [24] Synthesis and antitumor activity of gold(I) N-heterocyclic carbene with dithiocarbamate and alkynyl complexes
    Chen, Qiu Mei
    Zeng, Yanyan
    Zhang, Ming Rui
    Jin, Lingyu
    Zhou, Ping
    Wu, Xiang Hua
    Ren, Wen Xiu
    INORGANICA CHIMICA ACTA, 2024, 568
  • [25] Comparative in Vitro Evaluation of N-Heterocyclic Carbene Gold(I) Complexes of the Benzimidazolylidene Type
    Rubbiani, Riccardo
    Can, Suzan
    Kitanovic, Igor
    Alborzinia, Hamed
    Stefanopoulou, Maria
    Kokoschka, Malte
    Moenchgesang, Susann
    Sheldrick, William S.
    Woelfl, Stefan
    Ott, Ingo
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (24) : 8646 - 8657
  • [26] Allyl Functionalized Benzimidazolium-Derived Ag(I)-N-Heterocyclic Carbene Complexes: Anti-Biofilm and Antimicrobial Properties
    Tutar, Ugur
    celik, Cem
    Sahin, Neslihan
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2022, 56 (01) : 54 - 60
  • [27] Silver(I) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties
    Gurbuz, Nevin
    Kaloglu, Nazan
    Kizrak, Umran
    Ozdemir, Ilknur
    Turkmen, Nese Basak
    Ciftci, Osman
    Ozdemir, Ismail
    Mansour, L.
    Naceur, Hamdi
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2020, 923
  • [28] Gold(I)-N-Heterocyclic Carbene Synthons in Organometallic Synthesis
    Scattolin, Thomas
    Tonon, Giovanni
    Botter, Eleonora
    Guillet, Sebastien G.
    Tzouras, Nikolaos V.
    Nolan, Steven P.
    CHEMISTRY-A EUROPEAN JOURNAL, 2023, 29 (58)
  • [29] Counterion-induced modulation in biochemical properties of nitrile functionalized silver(I)-N-heterocyclic carbene complexes
    Asekunowo, Patrick O.
    Haque, Rosenani A.
    JOURNAL OF COORDINATION CHEMISTRY, 2014, 67 (22) : 3649 - 3663
  • [30] Synthesis, spectroscopic properties and biological activity of new Cu(I) N-Heterocyclic carbene complexes
    Touj, N.
    Chakchouk-Mtibaa, A.
    Mansour, L.
    Harrath, A. H.
    Al-Tamimi, J.
    Mellouli, L.
    Ozdemir, I
    Yasar, S.
    Hamdi, N.
    JOURNAL OF MOLECULAR STRUCTURE, 2019, 1181 : 209 - 219
12345