ELECTROPHYSIOLOGICAL RESPONSES FROM VAGUS NERVE STIMULATION IN RATS

被引：22

作者：

Mollet, Lies ^{[1
]}

Raedt, Robrecht ^{[1
]}

Delbeke, Jean ^{[1
]}

El Tahry, Riem ^{[1
]}

Grimonprez, Annelies ^{[1
]}

Dauwe, Ine ^{[1
]}

De Herdt, Veerle ^{[1
]}

Meurs, Alfred ^{[1
]}

Wadman, Wytse ^{[2
]}

Boon, Paul ^{[1
]}

Vonck, Kristl ^{[1
]}

机构：

[1] Ghent Univ Hosp, Lab Clin & Expt Neurophysiol Neurobiol & Neuropsy, Dept Neurol, Inst Neurosci, B-9000 Ghent, Belgium

[2] Univ Amsterdam, Dept Neurobiol, Swammerdam Inst Life Sci, NL-1090 Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF NEURAL SYSTEMS | 2013年 / 23卷 / 06期

关键词：

Vagus nerve recording; nerve fiber type; laryngeal muscle potential; vagus nerve stimulation; LOCUS-COERULEUS; ELECTRICAL-STIMULATION; VAGAL-STIMULATION; PARTIAL SEIZURES; CUFF ELECTRODE; EPILEPSY; BRAIN; SUPPRESSION; PROJECTIONS; PARAMETERS;

D O I：

10.1142/S0129065713500275

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is unknown and the therapeutic outcome is highly variable. We investigated stimulation-induced vagus nerve electrophysiological responses in rats using various stimulation parameters. Conduction velocity, I-50, rheobase and chronaxie were calculated. We identified an early and late component corresponding to an afferent compound action potential (CAP) and a remote laryngeal motor-evoked potential (LMEP), respectively. The conduction velocity (CAP: 26.2 +/- 1.4m/s; LMEP: 32.4 +/- 2.4m/s) and I50 (CAP: 2.4 +/- 0.3mA; LMEP: 1.8 +/- 0.2mA) were significantly different for both components, the rheobase (CAP: 140 +/- 30 mu A; LMEP: 110 +/- 26 mu A) and chronaxie (CAP: 66 +/- 7 mu s; LMEP: 73 +/- 9 mu s) were not. Using a pulse of 10 mu s, the CAP saturated between 4-5 mA. Our method can be used to record VNS-induced electrophysiological responses in rats and provides an objective biomarker for electrical stimulation with various parameters in an experimental set-up. Our findings are potentially useful for clinical purposes in the sense that combination of VNS and recording of vagal nerve CAPs may help clinicians to determine the individual optimal intensity required to fully activate fast-conducting afferent fibers.

引用

页数：12

共 49 条

[1] Animal models for vagus nerve stimulation in epilepsy [J].

Aalbers, Marlien ;

Vles, Johan ;

Klinkenberg, Sylvia ;

Hoogland, Govert ;

Majoie, Marian ;

Rijkers, Kim .

EXPERIMENTAL NEUROLOGY, 2011, 230 (02) :167-175

[2] Cardiorespiratory variables and sensation during stimulation of the left vagus in patients with epilepsy [J].

Banzett, RB ;

Guz, A ;

Paydarfar, D ;

Shea, SA ;

Schachter, SC ;

Lansing, RW .

EPILEPSY RESEARCH, 1999, 35 (01) :1-11

[3] Vagus-nerve stimulation for the treatment of epilepsy [J].

Ben-Menachem, E .

LANCET NEUROLOGY, 2002, 1 (08) :477-482

[4] VAGUS NERVE-STIMULATION FOR TREATMENT OF PARTIAL SEIZURES .1. A CONTROLLED-STUDY OF EFFECT ON SEIZURES [J].

BENMENACHEM, E ;

MANONESPAILLAT, R ;

RISTANOVIC, R ;

WILDER, BJ ;

STEFAN, H ;

MIRZA, W ;

TARVER, WB ;

WERNICKE, JF ;

AUGUSTINSSON, L ;

BAROLAT, G ;

BONGARTZ, U ;

BERGEN, D ;

BUCHOLZ, R ;

BURCHIEL, K ;

FAUGHT, E ;

GEORGE, R ;

HUFNAGEL, A ;

KUZNIECKY, R ;

LANDY, H ;

MICHAEL, J ;

NARITOKU, D ;

PENCEK, T ;

RAMSAY, RE ;

REID, S ;

RICHARDSON, D ;

ROSENFELD, W ;

ROSENWASSER, R ;

SALINSKY, M ;

SLATER, J ;

SONNEN, A ;

STRELETZ, L ;

TALALLA, A ;

TREIG, T ;

UPTON, ARM ;

UTHMAN, B ;

WEGENER, K ;

WILLIS, J .

EPILEPSIA, 1994, 35 (03) :616-626

[5]

Boon P, 2007, ACTA NEUROCHIR SUPPL, V97, P273

[6] Electrical Stimulation for the Treatment of Epilepsy [J].

Boon, Paul ;

Raedt, Robrecht ;

de Herdt, Veerle ;

Wyckhuys, Tine ;

Vonck, Kristl .

NEUROTHERAPEUTICS, 2009, 6 (02) :218-227

[7] Vagus nerve stimulation for epilepsy: is output current correlated with acute response? [J].

Bunch, S. ;

DeGiorgia, C. M. ;

Krahl, S. ;

Britton, J. ;

Green, P. ;

Lancman, M. ;

Murphy, J. ;

Olejniczak, P. ;

Shih, J. ;

Heck, C. N. .

ACTA NEUROLOGICA SCANDINAVICA, 2007, 116 (04) :217-220

[8] Autonomic brainstem nuclei are linked to the hippocampus [J].

Castle, M ;

Comoli, E ;

Loewy, AD .

NEUROSCIENCE, 2005, 134 (02) :657-669

[9]

Castoro M., 2001, EXP NEUROL, V227, P62

[10] Vagus nerve stimulation: Analysis of device parameters in 154 patients during the long-term XE5 study [J].

DeGiorgio, CM ;

Thompson, J ;

Lewis, P ;

Arrambide, S ;

Naritoku, D ;

Handforth, A ;

Labar, D ;

Mullin, P ;

Heck, C .

EPILEPSIA, 2001, 42 (08) :1017-1020

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