New thoughts on the pathobiology of regimen-related mucosal injury

被引：26
作者：
Anthony, Lowell
Bowen, Joanne
Garden, Adam
Hewson, Ian
Sonis, Stephen
机构：
[1] Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Royal Melbourne Hosp, Parkville, Vic 3050, Australia
[3] LSUHSC, Stanley S Scott Canc Ctr, New Orleans, LA USA
[4] Univ Adelaide, Dept Med, Adelaide, SA 5001, Australia
[5] Royal Adelaide Hosp, Dept Med Oncol, Adelaide, SA 5000, Australia
[6] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA
来源：
SUPPORTIVE CARE IN CANCER | 2006年 / 14卷 / 06期
关键词：
mucosal injury; cancer theraphy; radiation; drugs; genetic influences;
D O I：
10.1007/s00520-006-0058-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Our understanding of the biological basis for mucosal barrier injury (mucositis) induced by cancer therapy with radiation or drugs continues to evolve. A patient's mucosal response to cancer therapy appears to be controlled by both global (i.e. gender, underlying systemic disease, race) and tissue specific (i.e. epithelial type, intrinsic endocrine system, local microbial environment, function) factors. Conclusion: Interactions of these elements, coupled with underlying genetic influences, most likely govern the risk, course and severity of regimen-related mucosal injury.
引用
收藏
页码：516 / 518
页数：3
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