Diagnostic and Therapeutic Uptake of Intrathyroid Metastasis of Midgut Neuroendocrine Tumor on 68Ga-DOTANOC PET/CT and 177Lu-DOTATATE Imaging

被引：1

作者：

Racaru, Lavinia Vija ^{[1
]}

Sinigaglia, Mathieu ^{[2
]}

Fontaine, Sebastien ^{[1
,3
]}

D'Aure, Dominique ^{[4
]}

Courbon, Frederic ^{[1
]}

Dierickx, Lawrence ^{[1
]}

机构：

[1] Inst Claudius Regaud, Inst Univ Cancerol Oncopole, Dept Nucl Med, Toulouse, France

[2] Inst Claudius Regaud, Inst Univ Cancerol Oncopole, Nucl Med Therapy Unit, Toulouse, France

[3] Inst Claudius Regaud, Inst Univ Cancerol Oncopole, Dept Radiol, Toulouse, France

[4] CHU Toulouse, Dept Pathol, Toulouse, France

来源：

CLINICAL NUCLEAR MEDICINE | 2019年 / 44卷 / 07期

关键词：

Ga PET; CT; somatostatin analog imaging; thyroid metastasis; neuroendocrine tumor; Lu therapy; THYROID-GLAND; CARCINOMA;

D O I：

10.1097/RLU.0000000000002586

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 58-year-old woman with 5-year history of grade 1 progressive metastatic intestinal neuroendocrine tumor with metachronous liver metastases initially treated by surgery and liver embolization underwent Ga-68-DOTANOC PET/CT before Lu-177-DOTATATE therapy. Ga-68-DOTANOC PET/CT revealed increased uptake in several liver metastases and right iliac lymph nodes, consistent with radiopeptide therapy, including a hypodense isthmic thyroid nodule. Fine needle ultrasound-guided biopsy of the thyroid nodule was realized. Immunohistochemistry was positive for CD56, chromogranin, and synaptophysin and negative for calcitonin, confirming neuroendocrine tumor intrathyroid metastasis. Lu-177-DOTATATE SPECT/CT showed therapeutic uptake on the thyroid metastasis.

引用

页码：E445 / E448

页数：4

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