High-Density Lipoprotein Infusions

被引：3

作者：

Takata, Kohei ^{[1
]}

Di Bartolo, Belinda A. ^{[1
]}

Nicholls, Stephen J. ^{[1
]}

机构：

[1] Univ Adelaide, South Australian Hlth & Med Res Inst, POB 11060, Adelaide, SA 5001, Australia

来源：

CARDIOLOGY CLINICS | 2018年 / 36卷 / 02期

关键词：

High-density lipoproteins; Lipids; Cardiovascular risk; Atherosclerosis; APOLIPOPROTEIN-A-I; CHOLESTEROL EFFLUX CAPACITY; CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; FECAL STEROID-EXCRETION; HDL CHOLESTEROL; CARDIOVASCULAR EVENTS; HEALTHY-VOLUNTEERS; LDL CHOLESTEROL; MIMETIC CER-001;

D O I：

10.1016/j.ccl.2017.12.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High-density lipoproteins (HDLs) have presented an attractive target for the development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.

引用

页码：311 / +

页数：6

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