Metabolic programming of macrophage functions and pathogens control

被引：90

作者：

Koo, Sue-jie ^{[1
]}

Garg, Nisha J. ^{[2
,3
]}

机构：

[1] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[2] UTMB, Dept Microbiol & Immunol, Galveston, TX USA

[3] UTMB, Inst Human Infect & Immun, Galveston, TX USA

来源：

REDOX BIOLOGY | 2019年 / 24卷

基金：

美国国家卫生研究院;

关键词：

PYRUVATE-DEHYDROGENASE KINASE; TRYPANOSOMA-CRUZI; PPAR-GAMMA; NITRIC-OXIDE; SUCCINATE-DEHYDROGENASE; ALTERNATIVE ACTIVATION; FOAM CELLS; OXIDATIVE-METABOLISM; IRON HOMEOSTASIS; APOPTOTIC CELLS;

D O I：

10.1016/j.redox.2019.101198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages (M phi) are central players in mediating proinflammatory and immunomodulatory functions. Unchecked M phi activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of M phi responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential M phi characteristics. The metabolic properties that control the polarization and response of M phi remain to be fully uncovered for use in managing infectious diseases. Here, we review the various metabolic states in M phi and how they influence the cell function.

引用

页数：12

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