Strategies to target drugs to gliomas and CNS metastases of solid tumors

被引：14

作者：

Kerklaan, B. Milojkovic ^{[1
,2
]}

van Tellingen, O. ^{[3
]}

Huitema, A. D. R. ^{[4
]}

Beijnen, J. H. ^{[4
,5
]}

Boogerd, W. ^{[6
]}

Schellens, J. H. M. ^{[1
,2
,5
]}

Brandsma, D. ^{[6
]}

机构：

[1] Netherlands Canc Inst Antoni van Leeuwenhoek, Dept Mol Pathol, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst Antoni van Leeuwenhoek, Dept Clin Pharmacol, NL-1066 CX Amsterdam, Netherlands

[3] Netherlands Canc Inst Antoni van Leeuwenhoek, Dept Preclin Pharmacol, NL-1066 CX Amsterdam, Netherlands

[4] Netherlands Canc Inst Antoni van Leeuwenhoek, Dept Pharm & Pharmacol, NL-1066 CX Amsterdam, Netherlands

[5] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Utrecht, Netherlands

[6] Netherlands Canc Inst Antoni van Leeuwenhoek, Dept Neurooncol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

来源：

JOURNAL OF NEUROLOGY | 2016年 / 263卷 / 03期

关键词：

Glioma; Brain metastases; Nanoparticles; Polymer-based nanocarriers; siRNA; Antibodies; BLOOD-BRAIN-BARRIER; GLUTATHIONE-COATED NANOPARTICLES; P-GLYCOPROTEIN; RADIATION-THERAPY; BREAST-CANCER; PHASE-III; IN-VIVO; VINCRISTINE CHEMOTHERAPY; GLIOBLASTOMA-MULTIFORME; MULTIDRUG-RESISTANCE;

D O I：

10.1007/s00415-015-7919-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood-brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

引用

页码：428 / 440

页数：13

共 129 条

[1] Extracellularly activatable nanocarriers for drug delivery to tumors [J].

Abouelmagd, Sara A. ;

Hyun, Hyesun ;

Yeo, Yoon .

EXPERT OPINION ON DRUG DELIVERY, 2014, 11 (10) :1601-1618

[2] Functional Delivery of siRNA in Mice Using Dendriworms [J].

Agrawal, Amit ;

Min, Dal-Hee ;

Singh, Neetu ;

Zhu, Haihao ;

Birjiniuk, Alona ;

von Maltzahn, Geoffrey ;

Harris, Todd J. ;

Xing, Deyin ;

Woolfenden, Stephen D. ;

Sharp, Phillip A. ;

Charest, Alain ;

Bhatia, Sangeeta .

ACS NANO, 2009, 3 (09) :2495-2504

[3] Discriminant analysis to classify glioma grading using dynamic contrast-enhanced MRI and immunohistochemical markers [J].

Awasthi, Rishi ;

Rathore, Ram K. S. ;

Soni, Priyanka ;

Sahoo, Prativa ;

Awasthi, Ashish ;

Husain, Nuzhat ;

Behari, Sanjay ;

Singh, Rohit K. ;

Pandey, Chandra M. ;

Gupta, Rakesh K. .

NEURORADIOLOGY, 2012, 54 (03) :205-213

[4] Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma [J].

Batchelor, Tracy T. ;

Mulholland, Paul ;

Neyns, Bart ;

Nabors, L. Burt ;

Campone, Mario ;

Wick, Antje ;

Mason, Warren ;

Mikkelsen, Tom ;

Phuphanich, Surasak ;

Ashby, Lynn S. ;

DeGroot, John ;

Gattamaneni, Rao ;

Cher, Lawrence ;

Rosenthal, Mark ;

Payer, Franz ;

Juergensmeier, Juliane M. ;

Jain, Rakesh K. ;

Sorensen, A. Gregory ;

Xu, John ;

Liu, Qi ;

van den Bent, Martin .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (26) :3212-3218

[5] Cerebral open flow microperfusion: A new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier [J].

Birngruber, Thomas ;

Ghosh, Arijit ;

Perez-Yarza, Veronica ;

Kroath, Thomas ;

Ratzer, Maria ;

Pieber, Thomas R. ;

Sinner, Frank .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2013, 40 (12) :864-871

[6] Comparison of gadolinium-DTPA and macromolecular gadolinium-DTPA-polylysine for contrast-enhanced pulmonary time-of-flight magnetic resonance angiography [J].

Bock, JC ;

Kaufmann, F ;

Felix, R .

INVESTIGATIVE RADIOLOGY, 1996, 31 (10) :652-657

[7] Brain tumor epidemiology: Consensus from the Brain Tumor Epidemiology Consortium [J].

Bondy, Melissa L. ;

Scheurer, Michael E. ;

Malmer, Beatrice ;

Barnholtz-Sloan, Jill S. ;

Davis, Faith G. ;

Il'Yasova, Dora ;

Kruchko, Carol ;

McCarthy, Bridget J. ;

Rajaraman, Preetha ;

Schwartzbaum, Judith A. ;

Sadetzki, Siegal ;

Schlehofer, Brigitte ;

Tihan, Tarik ;

Wiemels, Joseph L. ;

Wrensch, Margaret ;

Buffler, Patricia A. .

CANCER, 2008, 113 (07) :1953-1968

[8]

Brandsma D., 2014, ANN ONCOL, V25, piv146, DOI DOI 10.1093/ANN0NC/MDU331.32

[9] Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs [J].

Breedveld, P ;

Beijnen, JH ;

Schellens, JHM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2006, 27 (01) :17-24

[10] Phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) in low-grade glioma: RTOG 9802 with Alliance, ECOG, and SWOG [J].

Buckner, Jan C. ;

Pugh, Stephanie L. ;

Shaw, Edward G. ;

Gilbert, Mark R. ;

Barger, Geoffrey ;

Coons, Stephen ;

Ricci, Peter ;

Bullard, Dennis ;

Brown, Paul D. ;

Stelzer, Keith ;

Brachman, David ;

Suh, John H. ;

Schultz, Christopher J. ;

Bahary, Jean-Paul ;

Fisher, Barbara Jean ;

Kim, Harold ;

Murtha, Albert D. ;

Curran, Walter J. ;

Mehta, Minesh P. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)

← 1 2 3 4 5 6 7 8 9 10 →