Longevity of neutralizing antibody levels in macaques vaccinated with Quil A-adjuvanted measles vaccine candidates

被引：15
作者：
Stittelaar, KJ
Vos, HW
van Amerongen, G
Kersten, GFA
Osterhaus, ADME
de Swart, RL
机构：
[1] Erasmus MC, Inst Virol, NL-3000 DR Rotterdam, Netherlands
[2] Natl Inst Publ Hlth & Environm, Sector Vaccines, NL-3720 BA Bilthoven, Netherlands
来源：
VACCINE | 2002年 / 21卷 / 3-4期
关键词：
measles; iscom; Quil A;
D O I：
10.1016/S0264-410X(02)00453-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Quil A-based candidate measles vaccines have been shown to be immunogenic and protective in cotton rats and macaques. Here we studied the longevity of protective VN antibody levels induced in macaques with one dose of measles virus (MV) iscom. Inactivated MV adjuvanted with iscom-matrix or with purified Quillaja saponin QA-22 were also tested. All animals developed high levels of VN antibody and MV-specific IFNgamma-producing cells. Especially the high VN antibody levels induced by the latter two preparations showed virtually no decrease during the 2-year follow-up. These highly promising candidate MV vaccines should now be tested in infant macaques in the presence or absence of passively transferred and/or maternally derived VN antibodies. In addition, the immumopathological safety of the constructs should be evaluated in the atypical measles model in rhesus macaques. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：155 / 157
页数：3
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