Nanocrystalline copper(II) oxide catalyzed aza-Michael reaction and insertion of α-diazo compounds into N-H bonds of amines

被引：49

作者：

Kantam, M. Lakshmi ^{[1
]}

Laha, Soumi ^{[1
]}

Yadav, Jagjit ^{[1
]}

Jha, Shailendra ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500007, Andhra Pradesh, India

[2] Jadavpur Univ, Dept Chem, Kolkata, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 31期

关键词：

Nanocrystalline copper(II) oxide; Heterogeneous catalyst; Aza-Michael addition; alpha; beta-Unsaturated compounds; Insertion; Diazoacetate; EFFICIENT HETEROGENEOUS CATALYST; SOLVENT-FREE CONDITIONS; ONE-STEP SYNTHESIS; ALPHA; BETA-ETHYLENIC COMPOUNDS; RHODIUM CARBENOIDS; ENANTIOSELECTIVE SYNTHESIS; CONJUGATE ADDITION; ACID-DERIVATIVES; ALIPHATIC-AMINES; MGO;

D O I：

10.1016/j.tetlet.2009.05.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nanocrystalline copper(II) oxide efficiently catalyzed the conjugate addition of aliphatic amines to alpha,beta-unsaturated compounds to produce beta-amino compounds with excellent yields under mild reaction conditions. Similarly, Glycine esters are obtained in good yields by the insertion of alpha-diazoacetate into N-H bonds of amines. The catalyst is used for three cycles with minimal loss of activity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4467 / 4469

页数：3

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