Synthesis and biological evaluation of enantiopure thionitrites: The solid-phase synthesis and nitrosation of D-glutathione as a molecular probe

被引：8

作者：

Cavero, M

Hobbs, A

Madge, D

Motherwell, WB

Selwood, D

Potier, P

机构：

[1] UCL, Christopher Ingold Labs, Dept Chem, London WC1H 0AJ, England

[2] Wolfson Inst Biomed Res, London WC1E 6AU, England

[3] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0960-894X(00)00060-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The D-isomer of the naturally-occurring tripeptide glulathione (gamma-L-Glu-L-Cys-Gly, L-GSH) has been synthesised using the Fmoc solid phase peptide synthesis strategy. The D-GSH obtained has been nitrosated to give the D-isomer of the bioactive thionitrite, S-nitroso-L-glutathione. The biological activity of both enantiomers of S-nitrosoglutathione has been studied and compared to the activity of the D- and L-isomers of N-acetyl-S-nitrosopenicillamine (SNAP) and S-nitrosocysteine (CysNO). (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：641 / 644

页数：4

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