Poor immune responses to influenza vaccination in infants

被引：29

作者：

Kumagai, T

Nagai, K

Okui, T

Tsutsumi, H

Nagata, N

Yano, S

Nakayama, T

Okuno, Y

Kamiya, H

机构：

[1] Pediat Allergy & Infect Dis Soc Sapporo, Kumagai Pediat Clin, Atsubetsu Ku, Sapporo, Hokkaido 0040013, Japan

[2] Sapporo Med Univ, Sch Med, Dept Pediat, Chuo Ku, Sapporo, Hokkaido 0600061, Japan

[3] Hokkaido Inst Publ Hlth, Kita Ku, Sapporo, Hokkaido 0600819, Japan

[4] Kitasato Inst Life Sci, Lab Viral Infect 1, Minato Ku, Tokyo 1088462, Japan

[5] Osaka Inst Publ Hlth, Higashinari Ku, Osaka 5370025, Japan

[6] Mie Natl Hosp, Dept Pediat, Tsu, Mie 5140125, Japan

来源：

VACCINE | 2004年 / 22卷 / 25-26期

关键词：

influenza vaccine; antibody; lymphocyte transformation;

D O I：

10.1016/j.vaccine.2004.02.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twenty-two and 37 infants and young children received two doses of influenza HA vaccine before the 2001-2002 influenza season and before the 2002-2003 season, respectively. Two or three serial specimens were obtained, before and 1 month after the first vaccination as well as 1 month after the second vaccination. Infants showed a significantly poor HI antibody rise and lymphocyte response compared with young children aged greater than or equal to 12 months. Time kinetics of the lymphoproliferative responses to influenza antigen among young children varied whereas their activities in infants were typically negative before immunization and increased after vaccination. Infants responded poorly to HA influenza vaccine compared with young children. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3404 / 3410

页数：7

共 19 条

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