Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity

被引：525

作者：

Sanjabi, Shomyseh ^{[1
]}

Zenewicz, Lauren A. ^{[1
]}

Kamanaka, Masahito ^{[1
]}

Flavell, Richard A. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 04期

关键词：

GROWTH-FACTOR-BETA; REGULATORY T-CELLS; ROR-GAMMA-T; DENDRITIC CELLS; INTERLEUKIN-22; PROTECTS; INDUCIBLE FACTOR; HOST-DEFENSE; MOUSE MODEL; DIFFERENTIATION; CYTOKINE;

D O I：

10.1016/j.coph.2009.04.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cytokines play a major role in maintaining lymphocyte homeostasis under both steady-state and inflammatory conditions. Unregulated lymphocytes in steady-state conditions can lead to autoimmunity, whereas during inflammation they can cause excessive tissue damage. Regulatory cytokines function in combination with other environmental signals to properly modulate the function and the extent of lymphocyte activation. Many recent studies have highlighted the importance of regulatory cytokines in controlling the differentiation and function of lymphocytes under steady-state and inflammatory conditions, as well as minimizing tissue damage.

引用

页码：447 / 453

页数：7

共 64 条

[61] IL-2 is essential for TGF-β to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells [J].