Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity

被引：504
作者：
Sanjabi, Shomyseh [1 ]
Zenewicz, Lauren A. [1 ]
Kamanaka, Masahito [1 ]
Flavell, Richard A. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, New Haven, CT 06520 USA
[2] Howard Hughes Med Inst, Chevy Chase, MD USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 04期
关键词：
GROWTH-FACTOR-BETA; REGULATORY T-CELLS; ROR-GAMMA-T; DENDRITIC CELLS; INTERLEUKIN-22; PROTECTS; INDUCIBLE FACTOR; HOST-DEFENSE; MOUSE MODEL; DIFFERENTIATION; CYTOKINE;
D O I：
10.1016/j.coph.2009.04.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cytokines play a major role in maintaining lymphocyte homeostasis under both steady-state and inflammatory conditions. Unregulated lymphocytes in steady-state conditions can lead to autoimmunity, whereas during inflammation they can cause excessive tissue damage. Regulatory cytokines function in combination with other environmental signals to properly modulate the function and the extent of lymphocyte activation. Many recent studies have highlighted the importance of regulatory cytokines in controlling the differentiation and function of lymphocytes under steady-state and inflammatory conditions, as well as minimizing tissue damage.
引用
收藏
页码：447 / 453
页数：7
相关论文
共 64 条
  • [61] IL-2 is essential for TGF-β to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    Zheng, Song Guo
    Wang, Juhua
    Wang, Pu
    Gray, J. Dixon
    Horwitz, David A.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (04) : 2018 - 2027
  • [62] Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    Zheng, Yan
    Valdez, Patricia A.
    Danilenko, Dimitry M.
    Hu, Yan
    Sa, Susan M.
    Gong, Qian
    Abbas, Alexander R.
    Modrusan, Zora
    Ghilardi, Nico
    de Sauvage, Frederic J.
    Ouyang, Wenjun
    [J]. NATURE MEDICINE, 2008, 14 (03) : 282 - 289
  • [63] Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    Zheng, Yan
    Danilenko, Dimitry M.
    Valdez, Patricia
    Kasman, Ian
    Eastham-Anderson, Jeffrey
    Wu, Jianfeng
    Ouyang, Wenjun
    [J]. NATURE, 2007, 445 (7128) : 648 - 651
  • [64] TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
    Zhou, Liang
    Lopes, Jared E.
    Chong, Mark M. W.
    Ivanov, Ivaylo I.
    Min, Roy
    Victora, Gabriel D.
    Shen, Yuelei
    Du, Jianguang
    Rubtsov, Yuri P.
    Rudensky, Alexander Y.
    Ziegler, Steven F.
    Littman, Dan R.
    [J]. NATURE, 2008, 453 (7192) : 236 - U14
1234567