Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies

被引：70
作者：
Rakocevic, Goran
Raju, Raghavan
Semino-Mora, Cristina
Dalakas, Marinos C.
机构：
[1] NINDS, Neuromuscular Dis Sect, NIH, Bethesda, MD 20892 USA
[2] Uniformed Serv Univ Hlth Sci, Gastrointestinal & Liver Studies Lab, Bethesda, MD 20814 USA
来源：
NEUROLOGY | 2006年 / 67卷 / 06期
关键词：
D O I：
10.1212/01.wnl.0000237558.83349.d0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We report five of 38 patients with stiff person syndrome (SPS), who also had cerebellar disease, gait ataxia, dysarthria, and oculomotor dysfunction (SPS-Cer). Cerebellar manifestations either preceded SPS or occurred concurrently. Brain MRI was normal. The intrathecal production of glutamic acid decarboxylase antibodies was elevated. gamma-Aminobutyric acid-enhancing drugs and immunotherapies improved only the stiffness. SPS-Cer is a distinct subset of SPS causing a more severe and complex clinical phenotype.
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页码：1068 / 1070
页数：3
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