Determination of the elastic modulus of native collagen fibrils via radial indentation

被引:114
作者
Heim, August J.
Matthews, William G.
Koob, Thomas J.
机构
[1] Univ S Florida, Dept Phys, Tampa, FL 33620 USA
[2] Univ S Florida, Dept Chem Engn, Tampa, FL 33620 USA
关键词
D O I
10.1063/1.2367660
中图分类号
O59 [应用物理学];
学科分类号
摘要
The authors studied the elastic response of single, native collagen fibrils extracted from tissues of the inner dermis of the sea cucumber, Cucumaria frondosa, via local nanoscale indentation with an atomic force microscope (AFM). AFM imaging of fibrils under ambient conditions are presented, demonstrating a peak-to-peak periodicity, the d band, of dehydrated, unfixed fibrils to be similar to 64.5 nm. Radial indentation experiments were performed, and the measured value for the reduced modulus is 1-2 GPa. (c) 2006 American Institute of Physics.
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页数:3
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