Molecular genetics of atherosclerosis

被引：42

作者：

Roy, Himadri ^{[1
]}

Bhardwaj, Shalini ^{[1
]}

Yla-Herttuala, Seppo ^{[1
]}

机构：

[1] Univ Kuopio, Dept Mol Med & Biotechnol, AI Virtanen Inst, FIN-70211 Kuopio, Finland

来源：

HUMAN GENETICS | 2009年 / 125卷 / 5-6期

关键词：

CORONARY-ARTERY-DISEASE; ESTER TRANSFER PROTEIN; NITRIC-OXIDE SYNTHASE; INTIMA-MEDIA THICKNESS; DENSITY-LIPOPROTEIN CHOLESTEROL; C-REACTIVE PROTEIN; SINGLE NUCLEOTIDE POLYMORPHISMS; ISCHEMIC-HEART-DISEASE; APOLIPOPROTEIN A5 GENE; HEME OXYGENASE-1 GENE;

D O I：

10.1007/s00439-009-0654-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic polymorphisms significantly influence susceptibility to atherosclerotic vascular diseases. A large number of candidate genes, genetic polymorphisms and susceptibility loci associated with atherosclerotic diseases have been identified in recent years and their number is rapidly increasing. In this review we focus on some of the major candidate genes and genetic polymorphisms associated with human atherosclerotic vascular diseases.

引用

页码：467 / 491

页数：25

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