Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

被引：44
|
作者：
Sanderson, Eleanor [1 ,2 ]
Smith, George Davey [1 ,2 ]
Bowden, Jack [1 ,2 ]
Munafo, Marcus R. [1 ,3 ]
机构：
[1] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England
[2] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol BS8 2BN, Avon, England
[3] Univ Bristol, Sch Expt Psychol, UK Ctr Tobacco & Alcohol Studies, Bristol BS8 1TU, Avon, England
来源：
NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期
基金：
英国经济与社会研究理事会; 英国医学研究理事会;
关键词：
PLEIOTROPIC GENETIC-VARIANTS; GENOME-WIDE ASSOCIATION; INTELLIGENCE; HEALTH; LOCI; INFERENCE;
D O I：
10.1038/s41467-019-10679-y
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recent analyses have shown educational attainment to be associated with a number of health outcomes. This association may, in part, be due to an effect of educational attainment on smoking behaviour. In this study, we apply a multivariable Mendelian randomisation design to determine whether the effect of educational attainment on smoking behaviour is due to educational attainment or general cognitive ability. We use individual data from the UK Biobank study (N = 120,050) and summary data from large GWA studies of educational attainment, cognitive ability and smoking behaviour. Our results show that more years of education are associated with a reduced likelihood of smoking that is not due to an effect of general cognitive ability on smoking behaviour. Given the considerable physical harms associated with smoking, the effect of educational attainment on smoking is likely to contribute to the health inequalities associated with differences in educational attainment.
引用
收藏
页数：9
相关论文
共 25 条
  • [11] The effects of social origins and cognitive ability on educational attainment: Evidence from Britain and Sweden
    Bukodi, Erzsebet
    Erikson, Robert
    Goldthorpe, John H.
    ACTA SOCIOLOGICA, 2014, 57 (04) : 293 - 310
  • [12] Examining causal relationships between educational attainment and type 2 diabetes using genetic analysis: findings from the EPIC-InterAct study through Mendelian randomisation
    Macciotta, Alessandra
    Sacerdote, Carlotta
    Giachino, Claudia
    Di Girolamo, Chiara
    Franco, Matteo
    van der Schouw, Yvonne T.
    Zamora-Ros, Raul
    Weiderpass, Elisabete
    Domenighetti, Cloe
    Elbaz, Alexis
    Truong, Therese
    Agnoli, Claudia
    Bendinelli, Benedetta
    Panico, Salvatore
    Vineis, Paolo
    Christakoudi, Sofia
    Schulze, Matthias B.
    Katzke, Verena
    Bajracharya, Rashmita
    Dahm, Christina C.
    Dalton, Susanne Oksbjerg
    Colorado-Yohar, Sandra M.
    Moreno-Iribas, Conchi
    Etxezarreta, Pilar Amiano
    Sanchez, Maria Jose
    Forouhi, Nita G.
    Wareham, Nicholas
    Ricceri, Fulvio
    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 2024, : 373 - 379
  • [13] Pathways of Intergenerational Transmission of Advantages during Adolescence: Social Background, Cognitive Ability, and Educational Attainment
    Schulz, Wiebke
    Schunck, Reinhard
    Diewald, Martin
    Johnson, Wendy
    JOURNAL OF YOUTH AND ADOLESCENCE, 2017, 46 (10) : 2194 - 2214
  • [14] Role of lifestyle factors in mediating the effect of educational attainment on bone mineral density: a Mendelian randomization study
    Liu, Qian
    Tooki, Tiaeki
    Di, Dongsheng
    Zhou, Haolong
    Cui, Zhangbo
    Zhang, Ruyi
    Zhang, Jianli
    Yuan, Tingting
    Zhou, Tingting
    Luo, Xiao
    Ling, Danyang
    Wang, Qi
    ARCHIVES OF OSTEOPOROSIS, 2023, 18 (01)
  • [15] The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
    Johnsen, M. B.
    Vie, G. A.
    Winsvold, B. S.
    Bjorngaard, J. H.
    Asvold, B. O.
    Gabrielsen, M. E.
    Pedersen, L. M.
    Hellevik, A. I.
    Langhammer, A.
    Furnes, O.
    Flugsrud, G. B.
    Skorpen, F.
    Romundstad, P. R.
    Storheim, K.
    Nordsletten, L.
    Zwart, J. A.
    OSTEOARTHRITIS AND CARTILAGE, 2017, 25 (06) : 817 - 823
  • [16] Exploring the Relationships Between Autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-Ancestral American Sample
    Colbert, Sarah M. C.
    Keller, Matthew C.
    Agrawal, Arpana
    Johnson, Emma C.
    BEHAVIOR GENETICS, 2022, 52 (06) : 315 - 323
  • [17] Cognitive performance's critical role in the progression from educational attainment to moderate to vigorous physical activity: insights from a Mendelian randomization study
    Qi, Fang
    Jinmin, Zhang
    FRONTIERS IN PSYCHOLOGY, 2024, 15
  • [18] Associations of educational attainment and cognitive level of job with old age verbal ability and processing speed: The mediating role of chronic diseases
    Ihle, Andreas
    Oris, Michel
    Fagot, Delphine
    Chicherio, Christian
    van der Linden, Bernadette W. A.
    Sauter, Julia
    Kliegel, Matthias
    APPLIED NEUROPSYCHOLOGY-ADULT, 2018, 25 (04) : 356 - 362
  • [19] Increased educational attainment and its effect on child mortality in 175 countries between 1970 and 2009: a systematic analysis
    Gakidou, Emmanuela
    Cowling, Krycia
    Lozano, Rafael
    Murray, Christopher J. L.
    LANCET, 2010, 376 (9745) : 959 - 974
  • [20] You Can't Change Your Basic Ability, but You Work at Things, and That' s How We Get Hard Things Done: Testing the Role of Growth Mindset on Response to Setbacks, Educational Attainment, and Cognitive Ability
    Li, Yue
    Bates, Timothy C.
    JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL, 2019, 148 (09) : 1640 - 1655
123