Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

被引：44
|
作者：
Sanderson, Eleanor [1 ,2 ]
Smith, George Davey [1 ,2 ]
Bowden, Jack [1 ,2 ]
Munafo, Marcus R. [1 ,3 ]
机构：
[1] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England
[2] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol BS8 2BN, Avon, England
[3] Univ Bristol, Sch Expt Psychol, UK Ctr Tobacco & Alcohol Studies, Bristol BS8 1TU, Avon, England
来源：
NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期
基金：
英国经济与社会研究理事会; 英国医学研究理事会;
关键词：
PLEIOTROPIC GENETIC-VARIANTS; GENOME-WIDE ASSOCIATION; INTELLIGENCE; HEALTH; LOCI; INFERENCE;
D O I：
10.1038/s41467-019-10679-y
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recent analyses have shown educational attainment to be associated with a number of health outcomes. This association may, in part, be due to an effect of educational attainment on smoking behaviour. In this study, we apply a multivariable Mendelian randomisation design to determine whether the effect of educational attainment on smoking behaviour is due to educational attainment or general cognitive ability. We use individual data from the UK Biobank study (N = 120,050) and summary data from large GWA studies of educational attainment, cognitive ability and smoking behaviour. Our results show that more years of education are associated with a reduced likelihood of smoking that is not due to an effect of general cognitive ability on smoking behaviour. Given the considerable physical harms associated with smoking, the effect of educational attainment on smoking is likely to contribute to the health inequalities associated with differences in educational attainment.
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页数：9
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