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- [61] Local cortical surface complexity maps from spherical harmonic reconstructions[J]. NEUROIMAGE, 2011, 56 (03) : 961 - 973Yotter, Rachel A.Nenadic, IgorZiegler, GabrielThompson, Paul M.Gaser, Christian
Neurocognitive basis of repetition deficits in primary progressive aphasia
被引：33
作者：
Lukic, Sladjana
[1
]
Mandelli, Maria Luisa
[1
]
Welch, Ariane
[1
]
Jordan, Kesshi
[1
]
Shwe, Wendy
[1
]
Neuhaus, John
[1
]
Miller, Zachary
[1
]
Hubbard, H. Isabel
[2
]
Henry, Maya
[3
]
Miller, Bruce L.
[1
]
Dronkers, Nina F.
[4
,5
]
Gorno-Tempini, Maria Luisa
[1
]
机构：
[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, 675 Nelson Rising Lane,Suite 190, San Francisco, CA 94158 USA
[2] Univ Kentucky, Lexington, KY USA
[3] Univ Texas Austin, Austin, TX 78705 USA
[4] Univ Calif Berkeley, Berkeley, CA 94720 USA
[5] Univ Calif Davis, Davis, CA 95616 USA
基金：
美国国家卫生研究院;
关键词：
Cortical thickness;
Phrase repetition;
Length;
Semantics;
Primary progressive aphasia;
SHORT-TERM-MEMORY;
TRACTOGRAPHY DEPICTING DAMAGE;
SENSORY-MOTOR INTEGRATION;
CONDUCTION APHASIA;
WORKING-MEMORY;
ARCUATE FASCICULUS;
LOGOPENIC VARIANT;
ANATOMY;
CLASSIFICATION;
IMPAIRMENT;
D O I：
10.1016/j.bandl.2019.04.003
中图分类号：
R36 [病理学];
R76 [耳鼻咽喉科学];
学科分类号：
100104 ;
100213 ;
摘要：
Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.
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页码：35 / 45
页数：11
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