Drift reconstruction from first passage time data using the Levenberg-Marquardt method

被引:0
作者
Fok, Pak-Wing [1 ]
机构
[1] Univ Delaware, Dept Math Sci, Newark, DE 19716 USA
关键词
random walk; first passage times; drift reconstruction; force spectroscopy; FORCE SPECTROSCOPY; SIMULATION;
D O I
10.1080/17415977.2012.757313
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
In this paper, we consider the problem of recovering the drift function of a Brownian motion from its distribution of first passage times, given a fixed starting position. Our approach uses the backward Kolmogorov equation for the probability density function (pdf) of first passage times. By taking Laplace transforms, we reduce the problem to calculating the coefficient function in a second-order ordinary differential equation (ODE). The inverse problem effectively amounts to finding the convection coefficient of the ODE, given the transformed pdf for positive values of the Laplace variable. Our first contribution is to find series solutions to the forward problem and show that the associated operator for the linearized inverse problem is compact. Our second contribution is numerical: for low noise levels, we reconstruct simple drift functions by applying Tikhonov regularization and performing a Newton iteration (Levenberg-Marquardt method). For larger noise, our solution displays large oscillations about the true drift.
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页码:1288 / 1309
页数:22
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