Herbal Supplement Attenuation of Cardiac Fibrosis in Rats with CCl4-Induced Liver Cirrhosis

被引：13

作者：

Chang, Hsiao-Chuan ^{[1
]}

Chiu, Yung-Wei ^{[2
,3
,4
]}

Lin, Yueh-Min ^{[5
,6
]}

Chen, Ray-Jade ^{[7
]}

Lin, James A. ^{[8
]}

Tsai, Fuu-Jen ^{[9
]}

Tsai, Chang-Hai ^{[10
]}

Kuo, Yu-Chun ^{[8
]}

Liu, Jer-Yuh ^{[11
,12
]}

Huan, Chih-Yang ^{[8
,9
,13
]}

机构：

[1] Asia Univ, Dept Biotechnol, Taichung 41354, Taiwan

[2] Cluing Shan Med Univ, Inst Med, Taichung 40201, Taiwan

[3] Tungs Taichung MetroHarbor Hosp, Emergency Dept, Taichung 43549, Taiwan

[4] Tungs Taichung MetroHarbor Hosp, Ctr Hyperbar Oxygen Therapy, Taichung 43549, Taiwan

[5] Changluta Christian Hosp, Dept Pathol, Changhua, Taiwan

[6] Jen Teh Jr Coll Med,Nursing & Management, Dept Med Technol, Miaoli 35664, Taiwan

[7] Taipei Med Univ, Sch Med, Dept Surg, Coll Med, Taipei 11031, Taiwan

[8] China Med Univ, Grad Inst Basic Med Sci, Taichung 40402, Taiwan

[9] China Med Univ, Grad Inst Chinese Med Sci, Taichung 40402, Taiwan

[10] Asia Univ, Dept Healthcare Adm, Taichung 41354, Taiwan

[11] China Med Univ Hosp, Ctr Mol Med, Taichung 40447, Taiwan

[12] China Med Univ, Grad Inst Canc Biol, Taichung 40402, Taiwan

[13] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan

来源：

CHINESE JOURNAL OF PHYSIOLOGY | 2014年 / 57卷 / 01期

关键词：

cardiac fibrosis; CCl4; Ocimum gratissimum; silymarin; TGF-beta; OCIMUM-GRATISSIMUM; GROWTH; HYPERTROPHY; INHIBITION; EXPRESSION; PREVENTION; SILYMARIN; DISEASE;

D O I：

10.4077/CJP.2014.BAB147

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Previously we found carbon tetrachloride (CCl4) induced cirrhosis associated cardiac hypertrophy and apoptosis. The purpose of this study is to determine whether further CCl4 treatment would induce cardiac cell fibrosis. The cardiac tissues were analyzed by H&E. histological staining, Trichrome Masson staining and Western blotting. The results showed that the CCl4-treated-only group exhibits more trichrome staining, meaning that more fibrosis is present. Moreover, CCl4 could further induce cardiac-fibrosis via TGF-beta-p-Smad2/3-CTGF pathway. However, our data showed that the CCl4-indcued cardiac abnormalities were attenuated by Ocimum gratissimum extract (OGE) and silymarin co-treatments. In conclusion, our results indicated that the OGE and silymarin may be a potential traditional herb for the protection of cardiac tissues from the CCl4 induced cirrhosis associated cardiac fibrosis through modulating the TGF-beta signaling pathway.

引用

页码：41 / 47

页数：7

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