Hernia-repair prosthetic devices functionalised with chitosan and ciprofloxacin coating: controlled release and antibacterial activity

被引：59

作者：

Avetta, Paola ^{[1
]}

Nistico, Roberto ^{[1
,2
]}

Faga, Maria Giulia ^{[3
]}

D'Angelo, Domenico ^{[4
]}

Boot, Elisa Aimo ^{[4
]}

Lamberti, Roberta ^{[5
]}

Martorana, Selanna ^{[5
]}

Calza, Paola ^{[1
,2
]}

Fabbri, Debora ^{[1
]}

Magnacca, Giuliana ^{[1
,2
]}

机构：

[1] Univ Turin, Dept Chem, I-10125 Turin, Italy

[2] NIS Ctr Excellence, I-10125 Turin, Italy

[3] CNR, IMAMOTER, I-10135 Turin, Italy

[4] Plasma Nano Tech, Environment Pk SpA, I-10144 Turin, Italy

[5] Herniamesh SrL, I-10034 Chivasso, Italy

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 32期

关键词：

MESH-RELATED INFECTIONS; POLYPROPYLENIC FIBERS; THERMAL-DEGRADATION; POLYMERS; SUTURE; ACID;

D O I：

10.1039/c4tb00236a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Polypropylene nets are widely used as hernioplasty prostheses. The reproduction of bacteria within the net fibers intersections can occur after the application of the prosthesis causing infections. For this reason, bacteria have to be removed in the very early stage of surgical implantation. Activation of the prosthesis surface was done by an innovative oxidizing plasma treatment (APP-DBD) working under atmospheric conditions in order to favor the deposition of an antibacterial coating of chitosan (biocompatible carbohydrate) and ciprofloxacin (broad spectrum antibiotic). Two different coating mixtures were realised and the antibacterial properties of such functionalised nets were investigated, together with their effectiveness. Physico-chemical characterisations of meshes were carried out before and after functionalisation by SEM-EDS and infrared spectroscopy. The release of both chitosan and ciprofloxacin, under controlled experimental conditions, was followed respectively by colorimetric determination (using UV-Visible spectroscopy) and chromatographic analysis (using HPLC). In vitro tests allow verifying antimicrobial activity (inoculation of specimens in a Staphylococcus aureus suspension).

引用

页码：5287 / 5294

页数：8

共 31 条

[1] BIOMATERIALS FOR ABDOMINAL-WALL HERNIA SURGERY AND PRINCIPLES OF THEIR APPLICATIONS [J].