Systemic lupus erythematosus is associated with increased incidence of hematologic malignancies: A meta-analysis of prospective cohort studies

被引：37
作者：
Apora, Emmanuel [1 ,2 ]
O'Brien, Jennifer [1 ,2 ]
Stephen, Merin
Castillo, Jorge J. [3 ]
机构：
[1] Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA
[2] Miriam Hosp, Dept Med, Providence, RI 02906 USA
[3] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA
来源：
LEUKEMIA RESEARCH | 2014年 / 38卷 / 09期
关键词：
Lupus; Lymphoma; Leukemia; Myeloma; Incidence; Meta-analysis; CANCER-RISK; LYMPHOMA; SUBTYPES; BIAS;
D O I：
10.1016/j.leukres.2014.06.025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our objective was to define the risk of lymphoma, leukemia and myeloma in adult patients with SLE with a meta-analysis of prospective cohort studies. A literature search from 1995 to 2013 revealed eight studies evaluating this association. The outcome of interest was the standardized incidence ratio (SIR). Our study included 401 cases in a cohort of approximately 68,000 SLE patients, and showed an increased incidence of all hematologic malignancies (SIR 2.9), non-Hodgkin lymphoma (SIR 5.7), Hodgkin lymphoma (SIR 3.1), leukemia (SIR 2.3) and myeloma (SIR 1.5) in SLE patients compared with the general population. The increased SIR was consistent regardless of age, sex or geographical region. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1067 / 1071
页数：5
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