What do we know about DNA mechanics so far?

被引：34
作者：
Aggarwal, Abhishek [1 ]
Naskar, Supriyo [1 ]
Sahoo, Anil Kumar [1 ]
Mogurampelly, Santosh [2 ]
Garai, Ashok [3 ]
Maiti, Prabal K. [1 ]
机构：
[1] Indian Inst Sci, Ctr Condensed Matter Theory, Dept Phys, Bangalore 560012, Karnataka, India
[2] Indian Inst Technol Jodhpur, Dept Phys, Jodhpur 342037, Rajasthan, India
[3] LNM Inst Informat Technol, Dept Phys, Jaipur 302031, Rajasthan, India
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2020年 / 64卷
关键词：
STRANDED-DNA; SINGLE; ELASTICITY; LENGTH; FLEXIBILITY; TWIST; RNA;
D O I：
10.1016/j.sbi.2020.05.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and finds applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions.
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页码：42 / 50
页数：9
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