Recent Advancements in the Loading and Modification of Therapeutic Exosomes

被引：118
作者：
Xu, Mengqiao [1 ,2 ,3 ,4 ,5 ]
Yang, Qianhao [6 ]
Sun, Xiaodong [1 ,2 ,3 ,4 ,5 ]
Wang, Yue [7 ,8 ]
机构：
[1] Shanghai Gen Hosp, Shanghai, Peoples R China
[2] Natl Clin Res Ctr Eye Dis, Shanghai, Peoples R China
[3] Shanghai Key Lab Ocular Fundus Dis, Shanghai, Peoples R China
[4] Shanghai Engn Ctr Visual Sci & Photomed, Shanghai, Peoples R China
[5] Shanghai Engn Ctr Precise Diag & Treatment Eye Di, Shanghai, Peoples R China
[6] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped Surg, Shanghai, Peoples R China
[7] Second Mil Med Univ, Dept Histol & Embryol, Shanghai, Peoples R China
[8] Shanghai Key Lab Cell Engn, Shanghai, Peoples R China
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
exosome; drug delivery; engineering strategy; content loading; surface modification; DRUG-DELIVERY VEHICLES; INHIBIT IN-VITRO; EXTRACELLULAR VESICLES; TUMOR-GROWTH; MEDIATED DELIVERY; CANCER; PACLITAXEL; PROTEINS; SIRNA; BRAIN;
D O I：
10.3389/fbioe.2020.586130
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Exosomes have a rapid development of bio-nanoparticles for drug delivery and confluent advances in next-generation diagnostics, monitoring the progression of several diseases, and accurate guidance for therapy. Based on their prominent stability, cargo-carriage properties, stable circulating capability, and favorable safety profile, exosomes have great potential to regulate cellular communication by carrying variable cargoes into specific site. However, the specific loading strategies and modification methods for engineered exosomes to enhance the targeting ability are unclear. The clinical application of exosomes is still limited. In this review, we discuss both original and modified exosomes for loading specific therapeutic molecules (proteins, nucleic acids, and small molecules) and the design strategies used to target specific cells. This review can be used as a reference for further loading and modification strategies as well as for the therapeutic applications of exosomes.
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页数：12
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