14N nuclear quadrupole resonance of some sulfa drugs

被引：33
作者：
Blinc, Robert
Seliger, Janez
Zidansek, Aleksander
Zagar, Veselko
Milia, Fani
Robert, Hector
机构：
[1] J Stefan Inst, Ljubljana 1000, Slovenia
[2] Jozef Stefan Int Postgrad Sch, Ljubljana, Slovenia
[3] Univ Ljubljana, Fac Math & Phys, Ljubljana 1000, Slovenia
[4] NCSR Demokritos, Athens, Greece
[5] Quantum Magnet Inc, GE Secur, San Diego, CA 92128 USA
来源：
SOLID STATE NUCLEAR MAGNETIC RESONANCE | 2006年 / 30卷 / 02期
关键词：
polymorphs; sulfa drugs; N-14 nuclear quadrupole resonance;
D O I：
10.1016/j.ssnmr.2006.02.003
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The N-14 nuclear quadrupole double resonance spectra of different polymorphs of sulfanilamide, sulfadiazine, sulfamerazine and sulfamethazine have been measured and the N-14 quadrupole coupling tensors have been determined. The obtained N-14 spectra are compared with those of other sulfa drugs like sulfathiazole. It is shown that different polymorphs can be easily discriminated. The application of this technique for non-destructive analysis, polymorph determination and quality control in the production of pharmaceuticals is stressed. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：61 / 68
页数：8
相关论文
共 24 条
[1]   Potential of nuclear quadrupole resonance in pharmaceutical analysis [J].
Balchin, E ;
Malcolme-Lawes, DJ ;
Poplett, LJF ;
Rowe, MD ;
Smith, JAS ;
Pearce, GES ;
Wren, SAC .
ANALYTICAL CHEMISTRY, 2005, 77 (13) :3925-3930
[2]   STRUCTURE OF SULFAMETHAZINE [4-AMINO-N-(4,6-DIMETHYL-2-PYRIMIDINYL)BENZENESULPHONAMIDE], C12H14N4O2S [J].
BASAK, AK ;
MAZUMDAR, SK ;
CHAUDHURI, S .
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1983, 39 (APR) :492-494
[3]   Nuclear quadrupole double resonance techniques for the detection of explosives and drugs [J].
Blinc, R ;
Apih, T ;
Seliger, J .
APPLIED MAGNETIC RESONANCE, 2004, 25 (3-4) :523-534
[4]  
BUSSANDRI A, COMMUNICATION
[5]   N-14 NUCLEAR-QUADRUPOLE RESONANCE STUDY OF SUBSTITUTED ANILINES AND PREDICTION OF INVITRO ACTIVITY OF SULFANILAMIDES [J].
GREENBAUM, SG ;
SUBBARAO, SN ;
BRAY, PJ ;
OJA, T .
ORGANIC MAGNETIC RESONANCE, 1980, 14 (05) :379-383
[6]   NITROGEN ATOM ORBITAL POPULATIONS IN AZABENZENES AS DETERMINED BY THEIR 14N NUCLEAR QUADRUPOLE COUPLING CONSTANTS [J].
GUIBE, L ;
LUCKEN, EAC .
MOLECULAR PHYSICS, 1966, 10 (03) :273-&
[7]   NUCLEAR DOUBLE RESONANCE IN ROTATING FRAME [J].
HARTMANN, SR ;
HAHN, EL .
PHYSICAL REVIEW, 1962, 128 (05) :2042-&
[8]   A new polymorph of sulfathiazole [J].
Hughes, DS ;
Hursthouse, MB ;
Threlfall, T ;
Tavener, S .
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1999, 55 :1831-1833
[9]  
*JAICI, NQR DAT
[10]   N-14 NUCLEAR-QUADRUPOLE RESONANCE IN NICOTINIC-ACID DERIVATIVES [J].
KIM, NS ;
BRAY, PJ .
ORGANIC MAGNETIC RESONANCE, 1981, 15 (04) :370-374
123