Expedient Organocatalytic Aza-Morita-Baylis-Hillman Reaction through Ball-Milling

被引：26
|
作者：
Williams, Matthew T. J. [1 ]
Morrill, Louis C. [1 ]
Browne, Duncan L. [2 ]
机构：
[1] Cardiff Univ, Sch Chem, Cardiff Catalysis Inst, Cardiff CF10 3AT, Wales
[2] UCL, Sch Pharm, London WC1N 1AX, England
来源：
ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2020年 / 8卷 / 48期
基金：
英国工程与自然科学研究理事会;
关键词：
Mechanochemistry; Organocatalysis; Metal-free; Solvent-free; Reaction methodology; METHYL VINYL KETONE; N-TOSYLATED IMINES; MECHANOCHEMISTRY; COCRYSTAL; ACROLEIN; ACRYLATE; NEAT;
D O I：
10.1021/acssuschemeng.0c07320
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A ball-milling enabled tertiary amine catalyzed aza-Morita-Baylis-Hillman reaction is reported. The reaction process does not require solvent, has significantly shorter reaction times than previous methods and is reported on a range of imines and acrylate Michael acceptors across than 26 examples. A 12-fold scaled-up example is also reported as well as experimental comparisons to solution-based experiments and neat-stirred reactions.
引用
收藏
页码：17876 / 17881
页数：6
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