Family and Genetic Association Studies of Bipolar Disorder in Children

被引：24

作者：

Mick, Eric ^{[1
,2
]}

Faraone, Stephen V. ^{[3
,4
]}

机构：

[1] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA

[4] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA

来源：

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 02期

关键词：

Bipolar disorder; Childhood; Genetics; Comorbidity; Age at onset; DEFICIT HYPERACTIVITY DISORDER; DOPAMINE TRANSPORTER GENE; GENOME-WIDE ASSOCIATION; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; EARLY ADOLESCENT BIPOLARITY; MANIC-DEPRESSIVE ILLNESS; PROSPECTIVE FOLLOW-UP; ONSET MOOD DISORDER; NEUROTROPHIC FACTOR; LINKAGE DISEQUILIBRIUM;

D O I：

10.1016/j.chc.2008.11.008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The risk of bipolar disorder (BPD) (15-42%) in first-degree relatives of children with BPD are consistently larger than the 8.7% estimate of recurrence risk of BPD in first-degree relatives of adult BPD cases. There have been no family linkage studies of pediatric BPD, but secondary analyses of adult linkage samples suggest that early-onset BPD both increases the strength of associations in linkage studies. Positive associations with pediatric BPD and the BDNF gene (VaII66), the GAD1 gene (4s2241165), and the dopamine transporter gene (rs41084) have been reported but none of these associations have been replicated in independent samples. The number of informative families examined so far is quite small and studies were vastly underpowered to detect small effects. An adequately powered sample will likely require collaborative ascertainment of cases and families from multiple sites using valid and accepted measures of pediatric BPD.

引用

页码：441 / +

页数：14

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