Analysis of X-ray-induced aberrations in human chromosome 5 using high-resolution multicolour banding FISH (mBAND)

被引：39
|
作者：
Johannes, C
Chudoba, I
Obe, G
机构：
[1] Univ Essen Gesamthsch, Dept Genet, D-45117 Essen, Germany
[2] MetaSyst, D-68804 Altlussheim, Germany
来源：
CHROMOSOME RESEARCH | 1999年 / 7卷 / 08期
关键词：
chromosomal aberrations; human chromosome 5; mBAND; X-irradiation;
D O I：
10.1023/A:1009284018942
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peripheral lymphocytes were exposed to 4 Gy X-rays and aberrations were analysed in human chromosome 5 using high-resolution multicolour banding fluorescence in-situ hybridization (mBAND). This method is suited to detect simple and complex aberrations including peri- and paracentric inversions and exchanges between both chromosomes 5. Additionally, breakpoints can be assigned to specific regions in chromosome 5. Quantitative relationships of induced aberration types are discussed.
引用
收藏
页码：625 / 633
页数：9
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