Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant

被引：21

作者：

Barreto, Antonio C. H. ^{[1
,2
]}

Santiago, Vivian R. ^{[1
,2
]}

Freire, Rafael M. ^{[1
]}

Mazzetto, Selma E. ^{[2
]}

Denardin, Juliano C. ^{[3
]}

Mele, Giuseppe ^{[4
]}

Cavalcante, Igor M. ^{[5
]}

Ribeiro, Maria E. N. P. ^{[5
]}

Ricardo, Nagila M. P. S. ^{[5
]}

Goncalves, Tamara ^{[6
]}

Carbone, Luigi ^{[7
]}

Lemos, Telma L. G. ^{[5
]}

Pessoa, Otilia D. L. ^{[5
]}

Fechine, Pierre B. A. ^{[1
]}

机构：

[1] Univ Fed Ceara, Adv Mat Chem Grp GQMAT, Analyt & Phys Chem Dept, BR-60451970 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Organ & Inorgan Chem, Prod Lab & Proc Technol LPT, BR-12100 Fortaleza, Ceara, Brazil

[3] Santiago Univ Chile USACH, Dept Phys, Santiago 9160000, Chile

[4] Univ Salento, Dept Engn Innovat, I-73100 Lecce, Italy

[5] Univ Fed Ceara, Dept Organ & Inorgan Chem, LPIM, BR-12100 Fortaleza, Ceara, Brazil

[6] Univ Fed Ceara, Dept Pharm, BR-12100 Fortaleza, Ceara, Brazil

[7] Nanosci Inst CNR, Natl Nanotechnol Lab, I-73100 Lecce, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 09期

关键词：

drug delivery; cancer therapy; magnetic nanoparticles; oncocalyxone A; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; RELEASE; CORDIACHROMES;

D O I：

10.3390/ijms140918269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.

引用

页码：18269 / 18283

页数：15

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