Mechanisms of pathogen entry through the endosomal compartments

被引：281
作者：
Gruenberg, Jean
van der Goot, F. Gisou
机构：
[1] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland
[2] Univ Geneva, Dept Microbiol & Mol Med, CH-1211 Geneva, Switzerland
[3] Ecole Polytech Fed Lausanne, Inst Global Hlth, CH-1015 Lausanne, Switzerland
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 07期
关键词：
D O I：
10.1038/nrm1959
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Several pathogens-bacteria, viruses and parasites-must enter mammalian cells for survival, replication and immune-system evasion. These pathogens generally make use of existing cellular pathways that are designed for nutrient uptake, receptor downregulation and signalling. Because most of these pathways end in lysosomes, an organelle that is capable of killing microorganisms, pathogens have developed remarkable means to avoid interactions with this lytic organelle.
引用
收藏
页码：495 / 504
页数：10
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