Mechanisms of pathogen entry through the endosomal compartments

被引：281
作者：
Gruenberg, Jean
van der Goot, F. Gisou
机构：
[1] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland
[2] Univ Geneva, Dept Microbiol & Mol Med, CH-1211 Geneva, Switzerland
[3] Ecole Polytech Fed Lausanne, Inst Global Hlth, CH-1015 Lausanne, Switzerland
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 07期
关键词：
D O I：
10.1038/nrm1959
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Several pathogens-bacteria, viruses and parasites-must enter mammalian cells for survival, replication and immune-system evasion. These pathogens generally make use of existing cellular pathways that are designed for nutrient uptake, receptor downregulation and signalling. Because most of these pathways end in lysosomes, an organelle that is capable of killing microorganisms, pathogens have developed remarkable means to avoid interactions with this lytic organelle.
引用
收藏
页码：495 / 504
页数：10
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  • [91] Molecular and functional aspects of parasite invasion
    Soldati, D
    Foth, BJ
    Cowman, AF
    [J]. TRENDS IN PARASITOLOGY, 2004, 20 (12) : 567 - 574
  • [92] The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
    Späth, GF
    Garraway, LA
    Turco, SJ
    Beverley, SM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) : 9536 - 9541
  • [93] Linking albinism and immunity: The secrets of secretory lysosomes
    Stinchcombe, J
    Bossi, G
    Griffiths, GM
    [J]. SCIENCE, 2004, 305 (5680) : 55 - 59
  • [94] LYSOSOME RECRUITMENT AND FUSION ARE EARLY EVENTS REQUIRED FOR TRYPANOSOME INVASION OF MAMMALIAN-CELLS
    TARDIEUX, I
    WEBSTER, P
    RAVESLOOT, J
    BORON, W
    LUNN, JA
    HEUSER, JE
    ANDREWS, NW
    [J]. CELL, 1992, 71 (07) : 1117 - 1130
  • [95] Exosomes:: Composition, biogenesis and function
    Théry, C
    Zitvogel, L
    Amigorena, S
    [J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (08) : 569 - 579
  • [96] Type III secretion: More systems than you think
    Troisfontaines, P
    Cornelis, GR
    [J]. PHYSIOLOGY, 2005, 20 : 326 - 339
  • [97] Cell biology of antigen processing in vitro and in vivo
    Trombetta, ES
    Mellman, I
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 : 975 - 1028
  • [98] Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins
    Tweten, RK
    [J]. INFECTION AND IMMUNITY, 2005, 73 (10) : 6199 - 6209
  • [99] The UIM domain of Hrs couples receptor sorting to vesicle formation
    Urbé, S
    Sachse, M
    Row, PE
    Preisinger, C
    Barr, FA
    Strous, G
    Klumperman, J
    Clague, MJ
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (20) : 4169 - 4179
  • [100] Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
    Vergne, I
    Chua, J
    Lee, HH
    Lucas, M
    Belisle, J
    Deretic, V
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (11) : 4033 - 4038
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