Adrenic acid non-enzymatic peroxidation products in biofluids of moderate preterm infants

被引：9
作者：
Sanchez-Illana, Angel [1 ]
Shah, Vidhi [2 ]
David Pineiro-Ramos, Jose [1 ]
Di Fiore, Juliann M. [2 ,3 ]
Quintas, Guillermo [4 ,5 ]
Raffay, Thomas M. [2 ,3 ]
MacFarlane, Peter M. [2 ,3 ]
Martin, Richard J. [2 ,3 ]
Kuligowski, Julia [1 ]
机构：
[1] Hlth Res Inst La Fe, Neonatal Res Unit, Avda Fernando Abril Martorell 106, Valencia 46026, Spain
[2] Rainbow Babies & Childrens Hosp, Dept Pediat, Div Neonatol, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Cleveland, OH 44106 USA
[4] Leitat Technol Ctr, Hlth & Biomed, Avda Fernando Abril Martorell 106, Valencia 46026, Spain
[5] Hosp La Fe, Hlth Res Inst, Analyt Unit, Avda Fernando Abril Martorell 106, Valencia 46026, Spain
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2019年 / 142卷
关键词：
Dihomo-isoprostanes; Dihomo-isofurans; Lipid peroxidation; UPLC-MS/MS; Preterm infants; TANDEM MASS-SPECTROMETRY; IN-VIVO; DIHOMO-ISOFURANS; BIOMARKERS; F-2-DIHOMO-ISOPROSTANES; ISOPROSTANES; NEUROFURANS; DISCOVERY; F-2-ISOPROSTANES; NEUROPROSTANES;
D O I：
10.1016/j.freeradbiomed.2019.02.024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative stress plays an essential role in processes of signaling and damage to biomolecules during early perinatal life. Isoprostanoids and isofuranoids from the free radical-catalyzed peroxidation of polyunsaturated fatty acids (PUFAs) are widely recognized as reliable biomarkers of oxidative stress. However, their quantification is not straightforward due to high structural similarity of the compounds formed. In this work, a semi-quantitative method for the analysis of adrenic acid (AdA, C22:4 n-6) non-enzymatic peroxidation products (i.e. dihomo-isoprostanes and dihomo-isofurans) was developed. The proposed ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) method was applied to the analysis of blood plasma and urine from preterm infants providing information about AdA peroxidation.
引用
收藏
页码：107 / 112
页数：6
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