Intramolecular Didehydro-Diels-Alder Reaction for the Synthesis of Benzo-and Dihydrobenzo-Fused Heterocycles

被引：18

作者：

Bober, Ashley E. ^{[1
]}

Proto, Justin T. ^{[1
]}

Brummond, Kay M. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 07期

基金：

美国国家科学基金会;

关键词：

PALLADIUM-CATALYZED ADDITION; CLAISEN REARRANGEMENT; ARYLBORONIC ACID; PHARMACEUTICALS; INDOLES; ROUTE;

D O I：

10.1021/acs.orglett.7b00155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using an intramolecular didehydro-Diels-Alder reaction, ene-yne substituted pyrroles, thiophenes, and furans afford functionalized indoles, benzothiophenes, and benzofurans and the corresponding dihydroaromatic products. Product selectivity for the aromatic or dihydroaromatic product is controlled by the reaction conditions, which vary depending upon the substrate.

引用

页码：1500 / 1503

页数：4

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