Reversible inhibition of fertility in male rats with nifedipine

被引：0

作者：

Ratnasooriya, WD ^{[1
]}

Manikkavasagar, S ^{[1
]}

Wadsworth, RM ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PHYSIOL & PHARMACOL,GLASGOW G1 1XW,LANARK,SCOTLAND

来源：

MEDICAL SCIENCE RESEARCH | 1996年 / 24卷 / 11期

关键词：

nifedipine; calcium channel inhibitor; fertility;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Nifedipine, a dihydropyridine calcium channel blocking drug, was investigated for its effects on fertility of male rats. The drug was administered subcutaneously, on a single day, using different treatment regimens (0.05 mg kg(-1) once a day, 0.05 mg kg(-1) twice a day 0.1 mg kg(-1) once a day or 0.25 mg kg(-1) once a day). The highest dose of nifedipine inhibited fertility (measured by quantal pregnancy, fertility index and number of uterine implants) on day of administration. Fertility was restored by day 3 following treatment. The effective dose did not impair libido, ejaculatory competence (in terms of vaginal sperm numbers) or post-implantation losses but caused a significant elevation in preimplantation losses. It is concluded that nifedipine inhibited fertility by reducing fertilising potential of spermatozoa.

引用

页码：789 / 791

页数：3

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