A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes

被引：207

作者：

Culetto, E ^{[1
]}

Sattelle, DB ^{[1
]}

机构：

[1] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England

来源：

HUMAN MOLECULAR GENETICS | 2000年 / 9卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/hmg/9.6.869

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A growing number of medical research teams have begun to explore the experimental advantages of using a genetic animal model, the nematode worm Caenorhabditis elegans, with a view to enhancing our understanding of genes underlying human congenital disorders. In this study, we have compared sequences of positionally cloned human disease genes with the C.elegans database of predicted genes, Drawing on examples from spinal muscular atrophy, polycystic kidney disease, muscular dystrophy and Alzheimer's disease, we illustrate how data from C.elegans can yield new insights into the function and interactions of human disease genes.

引用

页码：869 / 877

页数：9

共 53 条

[1] A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe [J].