Chemical constituents of Chaenomeles sinensis twigs and their biological activity

被引：8

作者：

Cha, Joon Min ^{[1
]}

Kim, Dong Hyun ^{[1
]}

Subedi, Lalita ^{[2
]}

Khan, Zahra ^{[2
]}

Choi, Sang Un ^{[3
]}

Kim, Sun Yeou ^{[2
,4
]}

Kim, Chung Sub ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea

[2] Gachon Univ, Coll Pharm, 191 Hambakmoero, Incheon 21936, South Korea

[3] Korea Res Inst Chem Technol, Daejeon 34114, South Korea

[4] Gachon Univ, Gachon Inst Pharmaceut Sci, Incheon 21936, South Korea

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 16卷

基金：

新加坡国家研究基金会;

关键词：

antineuroinflammation; Chaenomeles sinensis; cytotoxicity; megastigmane; neurotrophic effect; BIOACTIVE TRITERPENOIDS; GLYCOSIDES; FRUITS; LEAVES;

D O I：

10.3762/bjoc.16.257

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

引用

页码：3078 / 3085

页数：8

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