Biological evaluation of chalcones and analogues as hypolipidemic agents

被引：23

作者：

Santos, Lorena

Pedrosa, Rozangela Curi ^{[1
]}

Correa, Rogerio

Cechinel Filho, Valdir

Nunes, Ricardo Jose

Yunes, Rosendo Augusto

机构：

[1] Univ Fed Santa Catarina, Dept Bioquim, Lab Bioquim Expt, Ctr Ciencias Biol, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Vale Itajai, UNIVALI, NIQFAR, Itajai, Brazil

来源：

ARCHIV DER PHARMAZIE | 2006年 / 339卷 / 10期

关键词：

chalcones analogues; cholesterol; hypolipidemic activity; triglycerides;

D O I：

10.1002/ardp.200600034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to evaluate the anti-hyperlipidemic effect of synthetic chalcones and some analogues, nineteen compounds with different substituents in both rings were synthesized and hypolipidemic activities were measured in vivo using Triton WR1339 acute and hypercaloric chronic assays. 4 ',4-dichlorochalcone, 3 ',4 ',4-trichlorochalcone, and 4 '-chlorochalcone gave an excellent decrease in serum total cholesterol and triglycerides in the acute assay. These compounds also showed significant anti-lipidemic activity in the chronic assay.

引用

页码：541 / 546

页数：6

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