Palladium-catalysed α-arylation of esters and amides under microwave conditions

被引：36
作者：
Bentz, E
Moloney, MG
Westaway, SM
机构：
[1] Univ Oxford, Dept Chem, Cent Res Lab, Oxford OX1 3TA, England
[2] GlaxoSmithKline Res Ltd, Dept Med Chem Neurol, Harlow CM19 5AW, Essex, England
[3] GlaxoSmithKline Res Ltd, GI CEDD, Harlow CM19 5AW, Essex, England
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 40期
基金：
英国工程与自然科学研究理事会;
关键词：
arylation; Reformatsky; catalysis; microwave;
D O I：
10.1016/j.tetlet.2004.08.074
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rapid and convenient approach for the alpha-arylation of esters and amides using Reformatsky reagents under a microwave accelerated reaction protocol has been established. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7395 / 7397
页数：3
相关论文
共 27 条
  • [1] BALME G, 1994, TETRAHEDRON, V50, P414
  • [2] Microwave-assisted Suzuki coupling on a KF-alumina surface: synthesis of polyaryls
    Basu, B
    Das, P
    Bhuiyan, MMH
    Jha, S
    [J]. TETRAHEDRON LETTERS, 2003, 44 (19) : 3817 - 3820
  • [3] Bremberg U, 2000, SYNTHESIS-STUTTGART, P1004
  • [4] MICROWAVE-ASSISTED ORGANIC-REACTIONS
    CADDICK, S
    [J]. TETRAHEDRON, 1995, 51 (38) : 10403 - 10432
  • [5] A practical method for the acylation of 2-imidazolidinone and 2-oxazolidinone chiral auxiliaries with 2-bromoacyl halides
    Candeias, SX
    Jenkins, K
    Ribeiro, ASC
    Afonso, CAM
    Caddick, S
    [J]. SYNTHETIC COMMUNICATIONS, 2001, 31 (21) : 3241 - 3254
  • [6] Palladium-catalyzed intermolecular α-arylation of N-protected 2-piperidinones
    Cossy, J
    de Filippis, A
    Pardo, DG
    [J]. ORGANIC LETTERS, 2003, 5 (17) : 3037 - 3039
  • [7] Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity
    Ersmark, K
    Feierberg, I
    Bjelic, S
    Hamelink, E
    Hackett, F
    Blackman, MJ
    Hultén, J
    Samuelsson, B
    Åqvist, J
    Hallberg, A
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (01) : 110 - 122
  • [8] The United Kingdom Chemical Database Service
    Fletcher, DA
    McMeeking, RF
    Parkin, D
    [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1996, 36 (04): : 746 - 749
  • [9] Palladium-catalyzed intramolecular α-arylation of α-amino acid esters
    Gaertzen, O
    Buchwald, SL
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (02) : 465 - 475
  • [10] Palladium-catalyzed α-arylation of esters and amides under more neutral conditions
    Hama, T
    Liu, XX
    Culkin, DA
    Hartwig, JF
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (37) : 11176 - 11177
123