One-step liquid-liquid extraction of cocaine from urine samples for gas chromatographic analysis

被引：24
|
作者：
Farina, M
Yonamine, M
Silva, OA
机构：
[1] Univ Sao Paulo, Coll Pharmaceut Sci, Dept Toxicol, BR-05508900 Sao Paulo, SP, Brazil
[2] Univ Reg Integrada Alto Urugaui & Missoes, Coll Pharm, BR-99700000 Erechim, RS, Brazil
来源：
FORENSIC SCIENCE INTERNATIONAL | 2002年 / 127卷 / 03期
关键词：
cocaine; urine analysis; liquid-liquid extraction; gas chromatography;
D O I：
10.1016/S0379-0738(02)00124-X
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
An improved technique for cocaine extraction from urine samples for gas chromatographic (GC) analysis is described. Employing a simple liquid-liquid extraction (LLE) of cocaine with a mixture of ethyl ether: isopropanol (9:1) the method presents a mean recovery of 74.49%. Limit of detection (LOD) and limit of quantification (LOQ) were 5 and 20 ng/ml, respectively. The method is highly precise (coefficient of variation (CV) <8%) and linear from 20 to 2000 ng/ml. It can he applied to detect the presence of cocaine in urine as a marker of its recent use in drug abuse treatment protocols. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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页码：204 / 207
页数：4
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