One-step liquid-liquid extraction of cocaine from urine samples for gas chromatographic analysis

被引：24
|
作者：
Farina, M
Yonamine, M
Silva, OA
机构：
[1] Univ Sao Paulo, Coll Pharmaceut Sci, Dept Toxicol, BR-05508900 Sao Paulo, SP, Brazil
[2] Univ Reg Integrada Alto Urugaui & Missoes, Coll Pharm, BR-99700000 Erechim, RS, Brazil
来源：
FORENSIC SCIENCE INTERNATIONAL | 2002年 / 127卷 / 03期
关键词：
cocaine; urine analysis; liquid-liquid extraction; gas chromatography;
D O I：
10.1016/S0379-0738(02)00124-X
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
An improved technique for cocaine extraction from urine samples for gas chromatographic (GC) analysis is described. Employing a simple liquid-liquid extraction (LLE) of cocaine with a mixture of ethyl ether: isopropanol (9:1) the method presents a mean recovery of 74.49%. Limit of detection (LOD) and limit of quantification (LOQ) were 5 and 20 ng/ml, respectively. The method is highly precise (coefficient of variation (CV) <8%) and linear from 20 to 2000 ng/ml. It can he applied to detect the presence of cocaine in urine as a marker of its recent use in drug abuse treatment protocols. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：204 / 207
页数：4
相关论文
共 50 条
  • [1] Rapid liquid-liquid extraction of cocaine from urine for gas chromatographic mass spectrometric analysis
    Garside, D
    Goldberger, BA
    Preston, KL
    Cone, EJ
    JOURNAL OF CHROMATOGRAPHY B, 1997, 692 (01): : 61 - 65
  • [2] Providing a Universal, One-step Alternative to Liquid-Liquid Extraction in Bioanalysis
    Wheaton, Jessalynn P.
    Chambers, Erin E.
    Fountain, Kenneth J.
    LC GC EUROPE, 2011, : 17 - 17
  • [3] Providing a Universal, One-Step Alternative to Liquid-Liquid Extraction in Bioanalysis
    Wheaton, Jessalynn P.
    Chambers, Erin E.
    Fountain, Kenneth J.
    LC GC NORTH AMERICA, 2011, : 62 - 62
  • [4] One-step in-syringe vortex-assisted liquid-liquid microextraction for the analysis of three fungicides in aqueous samples
    Wang, Xiangfang
    Cheng, Jing
    Xiao, Jing
    Wang, Xiuhong
    Chen, Mi
    Cheng, Min
    ANALYTICAL METHODS, 2013, 5 (08) : 2034 - 2040
  • [5] Improved determination of salicylaldoxime in water samples by liquid-liquid extraction followed by high performance liquid chromatographic analysis
    Kong Qian
    Bai Xiu-zhi
    Lin Hui-ju
    Li Hai-pu
    Yang Zhao-guang
    JOURNAL OF CENTRAL SOUTH UNIVERSITY, 2018, 25 (04) : 701 - 708
  • [6] GAS-LIQUID-CHROMATOGRAPHIC DETERMINATION OF COCAINE AND BENZOYLECGONINE IN URINE
    WALLACE, JE
    HAMILTON, HE
    KING, DE
    BASON, DJ
    SCHWERTNER, HA
    HARRIS, SC
    ANALYTICAL CHEMISTRY, 1976, 48 (01) : 34 - 38
  • [7] LIQUID-CHROMATOGRAPHIC DETERMINATION OF URINARY CATECHOLAMINES AFTER ONE-STEP ALUMINA EXTRACTION
    ANDERSON, GM
    DURKIN, TA
    MORTON, JB
    COHEN, DJ
    JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 424 (02): : 373 - 377
  • [8] Optimization of amphetamine extraction from biological samples by liquid-liquid extraction
    Raikos, Nikolaos
    Konstantina, Spagou
    Thessalonikeos, Elisavet
    Tsoukali, Heleni
    TOXICOLOGY LETTERS, 2008, 180 : S243 - S243
  • [9] One-step recycling of mineral acid from concentrated gold mining wastewater by high-temperature liquid-liquid extraction
    Moreira, Victor Rezende
    Rocha Lebron, Yuri Abner
    Gontijo, Debora
    Santos Amaral, Miriam Cristina
    SEPARATION AND PURIFICATION TECHNOLOGY, 2022, 286
  • [10] Rapid detection of methamphetamine in human fingernails by liquid-liquid extraction method and one-step methamphetamine test strip
    Solhi, Hassan
    Sanaei-Zadeh, Hossein
    Solhi, Sadra
    Badakhshan, Dariush
    Ghasemi, Shahab
    Sedeh, Bahman Sadeghi
    NATIONAL MEDICAL JOURNAL OF INDIA, 2018, 31 (02): : 67 - 69
12345