Understanding the effects of mature adipocytes and endothelial cells on fatty acid metabolism and vascular tone in physiological fatty tissue for vascularized adipose tissue engineering

被引：15

作者：

Huber, Birgit ^{[1
]}

Volz, Ann-Cathrin ^{[2
]}

Kluger, Petra J. ^{[2
,3
]}

机构：

[1] Univ Stuttgart, Inst Interfacial Proc Engn & Plasma Technol, D-70569 Stuttgart, Germany

[2] Reutlingen Univ, PA&T, D-72762 Reutlingen, Germany

[3] IGB, Fraunhofer Inst Interfacial Engn & Biotechnol, D-70569 Stuttgart, Germany

来源：

CELL AND TISSUE RESEARCH | 2015年 / 362卷 / 02期

关键词：

Mature adipocytes; Endothelial cells; Co-culture; Vascularized fatty tissue engineering; Cross-talk; NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; GROWTH-FACTOR EGF; INSULIN SENSITIVITY; ANGIOTENSIN-II; IN-VITRO; EXTRACELLULAR-MATRIX; LIPOLYTIC FUNCTION; GLUCOSE-UPTAKE; CROSS-TALK;

D O I：

10.1007/s00441-015-2274-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Engineering of large vascularized adipose tissue constructs is still a challenge for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Communication between mature adipocytes and endothelial cells is important for homeostasis and the maintenance of adipose tissue mass but, to date, is mainly neglected in tissue engineering strategies. Thus, new co-culture strategies are needed to integrate adipocytes and endothelial cells successfully into a functional construct. This review focuses on the cross-talk of mature adipocytes and endothelial cells and considers their influence on fatty acid metabolism and vascular tone. In addition, the properties and challenges with regard to these two cell types for vascularized tissue engineering are highlighted.

引用

页码：269 / 279

页数：11

共 119 条

[1] CYP2J2 Targeting to Endothelial Cells Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet by Reprogramming Adipocyte Phenotype [J].

Abraham, Nader G. ;

Sodhi, Komal ;

Silvis, Anne M. ;

Vanella, Luca ;

Favero, Gaia ;

Rezzani, Rita ;

Lee, Craig ;

Zeldin, Darryl C. ;

Schwartzman, Michal L. .

HYPERTENSION, 2014, 64 (06) :1352-U413

[2] Visfatin: Structure, function and relation to diabetes mellitus and other dysfunctions [J].

Adeghate, Ernest .

CURRENT MEDICINAL CHEMISTRY, 2008, 15 (18) :1851-1862

[3] Endothelial Cell Heterogeneity [J].

Aird, William C. .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (01)

[4] Adipokines, inflammation, and the endothelium in diabetes [J].

Waleed Aldhahi ;

Osama Hamdy .

Current Diabetes Reports, 2003, 3 (4) :293-298

[5] Vascular Mechanobiology - Endothelial Cell Responses to Fluid Shear Stress - [J].

Ando, Joji ;

Yamamoto, Kimiko .

CIRCULATION JOURNAL, 2009, 73 (11) :1983-1992

[6]

Aoki S, 2003, CELL STRUCT FUNCT, V28, P55

[7] Adipose tissue behavior is distinctly regulated by neighboring cells and fluid flow stress: a possible role of adipose tissue in peritoneal fibrosis [J].

Aoki, Shigehisa ;

Udo, Kazuma ;

Morimoto, Hiroyuki ;

Ikeda, Satoshi ;

Takezawa, Toshiaki ;

Uchihashi, Kazuyoshi ;

Nishijima-Matsunobu, Aki ;

Noguchi, Mitsuru ;

Sugihara, Hajime ;

Toda, Shuji .

JOURNAL OF ARTIFICIAL ORGANS, 2013, 16 (03) :322-331

[8] Cellular Models for Understanding Adipogenesis, Adipose Dysfunction, and Obesity [J].

Armani, Andrea ;

Mammi, Caterina ;

Marzolla, Vincenzo ;

Calanchini, Matilde ;

Antelmi, Antonella ;

Rosano, Giuseppe M. C. ;

Fabbri, Andrea ;

Caprio, Massimiliano .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 110 (03) :564-572

[9] Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo [J].

Attane, C. ;

Daviaud, D. ;

Dray, C. ;

Dusaulcy, R. ;

Masseboeuf, M. ;

Prevot, D. ;

Carpene, C. ;

Castan-Laurell, I. ;

Valet, P. .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2011, 46 (01) :21-28

[10] Creating capillary networks within human engineered tissues: Impact of adipocytes and their secretory products [J].

Aubin, Kim ;

Vincent, Caroline ;

Proulx, Maryse ;

Mayrand, Dominique ;

Fradette, Julie .

ACTA BIOMATERIALIA, 2015, 11 :333-345

← 1 2 3 4 5 6 7 8 9 10 →