Animal Models of Fear Relapse

被引：68

作者：

Goode, Travis D. ^{[1
]}

Maren, Stephen ^{[1
]}

机构：

[1] Texas A&M Univ, Inst Neurosci TAMIN, College Stn, TX 77843 USA

来源：

ILAR JOURNAL | 2014年 / 55卷 / 02期

基金：

美国国家卫生研究院;

关键词：

anxiety; exposure therapy; extinction; fear; PTSD; relapse; resilience; stress; POSTTRAUMATIC-STRESS-DISORDER; MEDIAL PREFRONTAL CORTEX; PROLONGED EXPOSURE THERAPY; MULTIPLE MEMORY-SYSTEMS; TERM POTENTIATION LTP; CONDITIONED FEAR; EXTINGUISHED FEAR; SPONTANEOUS-RECOVERY; SEX-DIFFERENCES; RETRIEVAL CUE;

D O I：

10.1093/ilar/ilu008

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Whereas fear memories are rapidly acquired and enduring over time, extinction memories are slow to form and are susceptible to disruption. Consequently, behavioral therapies that involve extinction learning (e.g., exposure therapy) often produce only temporary suppression of fear and anxiety. This review focuses on the factors that are known to influence the relapse of extinguished fear. Several phenomena associated with the return of fear after extinction are discussed, including renewal, spontaneous recovery, reacquisition, and reinstatement. Additionally, this review describes recent work, which has focused on the role of psychological stress in the relapse of extinguished fear. Recent developments in behavioral and pharmacological research are examined in light of treatment of pathological fear in humans.

引用

页码：246 / 258

页数：13

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