Antidepressant treatment of depression: A metaanalysis

被引:86
作者
Joffe, R [1 ]
Sokolov, S [1 ]
Streiner, D [1 ]
机构
[1] MCMASTER UNIV,DEPT CLIN EPIDEMIOL & BIOSTAT,HAMILTON,ON L8N 3Z5,CANADA
来源
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 1996年 / 41卷 / 10期
关键词
depression; metaanalysis; antidepressant;
D O I
10.1177/070674379604101002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To carry out a metaanalysis of antidepressant studies to calculate the effect sizes for antidepressant effect in depressive disorder. Method: A metaanalysis of all antidepressant studies that included an active comparison drug as well as placebo was used to calculate the effect size. Articles were selected from a MEDLINE search for the period January 1966 to June 1995. Forty-nine studies were included in the metaanalysis. Results: The effect sizes for antidepressant treatment are moderately larger than for placebo. A larger effect size was observed in studies where objective diagnostic criteria for depression were used. Conclusions: We conclude that the superior efficacy of antidepressants over placebo can be demonstrated.
引用
收藏
页码:613 / 616
页数:4
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