Prenatal caffeine exposure induced renal developmental toxicity and transgenerational effect in rat offspring

被引：4
作者：
Zhao, Xiaoqi [1 ]
Li, Bin [1 ,3 ]
Xiong, Ying [1 ]
Xia, Zhiping [1 ]
Hu, Shuangshuang [1 ]
Sun, Zhaoxia [1 ]
Wang, Hui [1 ,2 ]
Ao, Ying [1 ,2 ]
机构：
[1] Wuhan Univ, Dept Pharmacol, Basic Med Sch, Wuhan 430071, Peoples R China
[2] Hubei Prov Key Lab Dev Originated Disorder, Wuhan 430071, Peoples R China
[3] Wuhan Univ, Dept Orthoped Surg, Zhongnan Hosp, Wuhan 430071, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2022年 / 165卷
基金：
中国国家自然科学基金;
关键词：
Prenatal caffeine exposure; Glomerulosclerosis; Renal AT2R; Glucocorticoid-insulin-like growth factor 1 axis; Intrauterine programming; Intergenerational transmission; LOW-BIRTH-WEIGHT; RENIN-ANGIOTENSIN SYSTEM; INTERGENERATIONAL TRANSMISSION; ADULT HYPERTENSION; GLUCOCORTICOIDS; RISK; CELLS; GLOMERULOSCLEROSIS; CONSEQUENCES; INHERITANCE;
D O I：
10.1016/j.fct.2022.113082
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Epidemiological studies revealed that prenatal caffeine exposure (PCE) is associated with adverse gestational outcomes and susceptibility to chronic diseases in offspring, yet the effects of PCE on glomerulosclerosis susceptibility in adult female offspring and its intergenerational transmission remain to be further investigated. Here, we found that PCE caused fetal kidney dysplasia and glomerulosclerosis of the female offspring. Besides, the kidney of F1 offspring in PCE group exhibited the "low expressional programming of AT2R " and "GC-IGF1 programming " alteration. Intergenerational genetic studies revealed that the renal defect and GC-IGF1 programming alteration was inherited to F2 adult female offspring derived from the female germ line, but Low expression of AT2R did not extend to the F2 female offspring. Taken together, PCE caused renal dysplasia and adult glomerulosclerosis in the F1 female offspring, which might be mediated by renal AT2R low expressional programming and GC-IGF1 axis alteration. Furthermore, PCE induced transgenerational toxicity on kidney, and GC-IGF1 programming alteration might be the potential molecular mechanism. This study provided experimental evidence for the mechanism study of the intergenerational inheritance of kidney developmental toxicity caused by PCE.
引用
收藏
页数：12
相关论文
共 75 条
[1]   Mesangial cell biology [J].
Abboud, Hanna E. .
EXPERIMENTAL CELL RESEARCH, 2012, 318 (09) :979-985
[2]   Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure [J].
Ao, Ying ;
Sun, Zhaoxia ;
Hu, Shuangshuang ;
Zuo, Na ;
Li, Bin ;
Yang, Shuailong ;
Xia, Liping ;
Wu, Yong ;
Wang, Linlong ;
He, Zheng ;
Wang, Hui .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2015, 287 (02) :128-138
[3]   Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study [J].
Bakker, Rachel ;
Steegers, Eric A. P. ;
Obradov, Aleksandra ;
Raat, Hein ;
Hofman, Albert ;
Jaddoe, Vincent W. V. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (06) :1691-1698
[4]   The Regenerative Potential of Parietal Epithelial Cells in Adult Mice [J].
Berger, Katja ;
Schulte, Kevin ;
Boor, Peter ;
Kuppe, Christoph ;
van Kuppevelt, Toin H. ;
Floege, Juergen ;
Smeets, Bart ;
Moeller, Marcus J. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 25 (04) :693-705
[5]   Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study [J].
Boylan, Sinead ;
Cade, Janet E. ;
Dolby, Vivien A. ;
Greenwood, Darren C. ;
Hay, Alastair W. M. ;
Kirk, Sara F. L. ;
Shires, Susan ;
Simpson, Nigel ;
Thomas, James D. ;
Walker, James ;
White, Kay L. M. ;
Wild, Christopher P. ;
Potdar, Neelam ;
Konje, Justin C. ;
Taub, Nicholas ;
Charvill, Jim ;
Chipps, Karen C. ;
Kassam, Shabira ;
Ghandi, Chetan ;
Cooke, Marcus S. .
BMJ-BRITISH MEDICAL JOURNAL, 2008, 337 :1334-1338
[6]   CONGENITAL OLIGONEPHROPATHY AND THE ETIOLOGY OF ADULT HYPERTENSION AND PROGRESSIVE RENAL INJURY [J].
BRENNER, BM ;
CHERTOW, GM .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1994, 23 (02) :171-175
[7]  
Briffa J.F., 2018, SEMIN CELL DEV BIOL, P30447
[8]   Transgenerational programming of nephron deficits and hypertension [J].
Briffa, Jessica F. ;
Wlodek, Mary E. ;
Moritz, Karen M. .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 103 :94-103
[9]   Mechanisms of Glucocorticoid Action During Development [J].
Busada, Jonathan T. ;
Cidlowski, John A. .
NUCLEAR RECEPTORS IN DEVELOPMENT AND DISEASE, 2017, 125 :147-170
[10]   Programmed hypertension in rats treated with a NF-κB inhibitor during nephrogenesis: renal mechanisms [J].
Canale, Daniele ;
Rodrigues, Mariliza V. ;
Ferreira, Daniele N. ;
Machado, Flavia G. ;
Veras, Mariana M. ;
Malheiros, Denise M. A. C. ;
Krieger, Jose E. ;
Fujihara, Clarice K. ;
Venturini, Gabriela ;
Zatz, Roberto .
HYPERTENSION RESEARCH, 2011, 34 (06) :693-700
12345678