Cationic rhodium(I)/modified-BINAP catalyzed [2+2+2] cycloaddition of alkynes with nitriles

被引：134

作者：

Tanaka, Ken ^{[1
]}

Suzuki, Nanami ^{[1
]}

Nishida, Goushi ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Grad Sch Engn, Dept Appl Chem, Koganei, Tokyo 1848588, Japan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 17期

关键词：

alkynes; catalysis; cycloaddition; nitriles; pyridines; rhodium;

D O I：

10.1002/ejoc.20060034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cationic rhodium(I)/modified-BINAP complexes catalyze a chemo- and regioselective [2+2+2] cycloaddition of a wide variety of alkynes and nitriles leading to highly functionalized pyridines under mild reaction conditions. The asymmetric variant of this reaction, enantioselective desymmetrization of substituted malononitriles, also proceeded to give enantio-enriched bicyclic pyridines which possess a tertiary or quaternary stereocenter. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006.

引用

页码：3917 / 3922

页数：6

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