Voltage- Driven Reversible Insertion into and Leaving from a Lipid Bilayer: Tuning Transmembrane Transport of Artificial Channels

被引：152

作者：

Si, Wen ^{[1
]}

Li, Zhan-Ting ^{[1
]}

Hou, Jun-Li ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 18期

关键词：

artificial channels; lipid bilayers; transmembrane transport; vesicles; voltage gating; SYNTHETIC ION CHANNELS; PUSH-PULL RODS; CHARGE MOVEMENT; ANION RECEPTORS; WATER; RECOGNITION; MEMBRANES; MODELS; ALAMETHICIN; PEPTIDES;

D O I：

10.1002/anie.201311249

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three new artificial transmembrane channel molecules have been designed and synthesized by attaching positively charged Arg-incorporated tripeptide chains to pillar[5]arene. Fluorescent and patch-clamp experiments revealed that voltage can drive the molecules to insert into and leave from a lipid bilayer and thus switch on and off the transport of K+ ions. One of the molecules was found to display antimicrobial activity toward Bacillus subtilis with half maximal inhibitory concentration (IC50) of 10M which is comparable to that of natural channel-forming peptide alamethicin.

引用

页码：4578 / 4581

页数：4

共 55 条

[21] Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections [J].

Hurdle, Julian G. ;

O'Neill, Alex J. ;

Chopra, Ian ;

Lee, Richard E. .

NATURE REVIEWS MICROBIOLOGY, 2011, 9 (01) :62-75

[22] Artificial ion channel formed by cucurbit[n]uril derivatives with a carbonyl group fringed portal reminiscent of the selectivity filter of K+ channels [J].

Jeon, YJ ;

Kim, H ;

Jon, S ;

Selvapalam, N ;

Oh, DH ;

Seo, I ;

Park, CS ;

Jung, SR ;

Koh, DS ;

Kim, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (49) :15944-15945

[23] The principle of gating charge movement in a voltage-dependent K+ channel [J].

Jiang, YX ;

Ruta, V ;

Chen, JY ;

Lee, A ;

MacKinnon, R .

NATURE, 2003, 423 (6935) :42-48

[24] TOTALLY SYNTHETIC VOLTAGE-DEPENDENT ION-CHANNEL [J].

KOBUKE, Y ;

UEDA, K ;

SOKABE, M .

CHEMISTRY LETTERS, 1995, (06) :435-436

[25] The distribution and targeting of neuronal voltage-gated ion channels [J].

Lai, Helen C. ;

Jan, Lily Y. .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (07) :548-562

[26] Complex interactions of pillar[5]arene with paraquats and bis(pyridinium) derivatives [J].

Li, Chunju ;

Xu, Qianqian ;

Li, Jian ;

Yao, Feina ;

Jia, Xueshun .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (07) :1568-1576

[27] Viologen-Mediated Assembly of and Sensing with Carboxylatopillar[5]arene-Modified Gold Nanoparticles [J].

Li, Hui ;

Chen, Dai-Xiong ;

Sun, Yu-Long ;

Zheng, Yue Bing ;

Tan, Li-Li ;

Weiss, Paul S. ;

Yang, Ying-Wei .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (04) :1570-1576

[28] α-Aminoxy Acids: New Possibilities from Foldamers to Anion Receptors and Channels [J].

Li, Xiang ;

Wu, Yun-Dong ;

Yang, Dan .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (10) :1428-1438

[29] Light-controlled ion channels formed by amphiphilic small molecules regulate ion conduction via cis-trans photoisomerization [J].

Liu, Tao ;

Bao, Chunyan ;

Wang, Haiyan ;

Lin, Yao ;

Jia, Huijuan ;

Zhu, Linyong .

CHEMICAL COMMUNICATIONS, 2013, 49 (87) :10311-10313

[30] Nanoelectronics from the bottom up [J].

Lu, Wei ;

Lieber, CharLes M. .

NATURE MATERIALS, 2007, 6 (11) :841-850

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