Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives

被引：30

作者：

Zhong, Xiaoxing ^{[1
]}

Dou, Guolan ^{[1
]}

Wang, Deming ^{[1
]}

机构：

[1] China Univ Min & Technol, Sch Safety Engn, Xuzhou 221116, Jiangsu, Peoples R China

来源：

MOLECULES | 2013年 / 18卷 / 11期

基金：

中国国家自然科学基金;

关键词：

pyrazolo[3,4-b]pyridine-6(7H)-one; recyclable polyethylene glycol; aqueous media; synthesis; METHYLENE-GAMMA-BUTYROLACTONES; MULTICOMPONENT REACTIONS; 3-COMPONENT REACTION; AQUEOUS-MEDIA; CLAISEN REARRANGEMENT; ACID; MICROWAVE; CATALYST;

D O I：

10.3390/molecules181113139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum's acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.

引用

页码：13139 / 13147

页数：9

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