Synthesis of Dihydropyrrole Derivatives by a Palladium-Catalyzed Heck and Suzuki Cross-Coupling Cascade Reaction

被引：17

作者：

Peng, Jinsong ^{[1
,2
]}

Zhao, Yan ^{[1
]}

Zhou, Jingjie ^{[1
]}

Ding, Yuehang ^{[1
]}

Chen, Chunxia ^{[1
]}

机构：

[1] Northeast Forestry Univ, Dept Chem & Chem Engn, Coll Sci, Harbin 150040, Peoples R China

[2] Northeast Forestry Univ, Postdoctoral Mobile Res Stn Forestry Engn, Harbin 150040, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 15期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

pyrroles; palladium; catalysis; tandem reactions; Heck reaction; Suzuki reaction; ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC-ADDITION; STEREOSELECTIVE-SYNTHESIS; CYCLIZATION REACTION; FACILE PREPARATION; DOMINO REACTIONS; ORGANIC HALIDES; 2,3-DIHYDROPYRROLES; AZIRIDINES; BROMOALKYNES;

D O I：

10.1055/s-0033-1341265

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient protocol for the synthesis of 5-aryl-2,3-dihydropyrroles, starting from N-tosyl-protected 2-methylprop-2-en-1-amine, alkynyl bromides, and arylboronic acids, is described. The sequential reaction sequence involves nucleophilic addition of the sulfonamide to the alkynyl bromide, followed by a palladium-catalyzed tandem intramolecular Heck and intermolecular Suzuki cross-coupling reaction of the bromoalkene adduct.

引用

页码：2051 / 2056

页数：6

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