Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise

被引：19

作者：

Pereira Batatinha, Helena Angelica ^{[1
]}

Diniz, Tiego Aparecido ^{[1
]}

de Souza Teixeira, Alexandre Abilio ^{[1
]}

Krueger, Karsten ^{[2
]}

Rosa-Neto, Jose Cesar ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Cell & Dev Biol, 1524 Prof Lineu Prestes Av, BR-05508000 Sao Paulo, SP, Brazil

[2] Leibniz Univ Hannover, Inst Sports Sci, Dept Exercise & Hlth, Hannover, Germany

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

autophagy; cancer; exercise; immunosenescence; neurodegeneration; SKELETAL-MUSCLE; STEM-CELLS; T-LYMPHOCYTE; MITOCHONDRIAL BIOENERGETICS; PARKINSONS-DISEASE; PHYSICAL-EXERCISE; INFLUENZA VACCINE; IMMUNE-RESPONSES; PROGENITOR CELLS; ACTIVATION;

D O I：

10.1002/jcp.28318

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration.

引用

页码：14883 / 14895

页数：13

共 122 条

[1] Stem cells, mitochondria and aging [J].

Ahlqvist, Kati J. ;

Suomalainen, Anu ;

Hamalainen, Riikka H. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2015, 1847 (11) :1380-1386

[2] Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging [J].

Ahlskog, J. Eric ;

Geda, Yonas E. ;

Graff-Radford, Neill R. ;

Petersen, Ronald C. .

MAYO CLINIC PROCEEDINGS, 2011, 86 (09) :876-884

[3] Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? [J].

Akbar, Arne N. ;

Henson, Sian M. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (04) :289-295

[4] Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress [J].

Akbar, Mohammed ;

Essa, Musthafa Mohamed ;

Daradkeh, Ghazi ;

Abdelmegeed, Mohamed A. ;

Choi, Youngshim ;

Mahmood, Lubna ;

Song, Byoung-Joon .

BRAIN RESEARCH, 2016, 1637 :34-55

[5]

Almeida MF, 2017, MOL BIOL CELL, V28

[6] CANCER PREVENTION IN THE OLDER INDIVIDUAL [J].

Balducci, Lodovico .

SEMINARS IN ONCOLOGY NURSING, 2016, 32 (03) :314-324

[7] Metabolic Syndrome, Aging and Involvement of Oxidative Stress [J].

Bonomini, Francesca ;

Rodella, Luigi Fabrizio ;

Rezzani, Rita .

AGING AND DISEASE, 2015, 6 (02) :109-120

[8] Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise [J].

Bonsignore, Maria R. ;

Morici, Giuseppe ;

Riccioni, Roberta ;

Huertas, Alice ;

Petrucci, Eleonora ;

Veca, Mario ;

Mariani, Gualtiero ;

Bonanno, Anna ;

Chimenti, Laura ;

Gioia, Maria ;

Palange, Paolo ;

Testa, Ugo .

JOURNAL OF APPLIED PHYSIOLOGY, 2010, 109 (01) :60-67

[9] Circulating hematopoietic progenitor cells in runners [J].

Bonsignore, MR ;

Morici, G ;

Santoro, A ;

Pagano, M ;

Cascio, L ;

Bonanno, A ;

Abate, P ;

Mirabella, F ;

Profita, M ;

Insalaco, G ;

Gioia, M ;

Vignola, AM ;

Majolino, I ;

Testa, U ;

Hogg, JC .

JOURNAL OF APPLIED PHYSIOLOGY, 2002, 93 (05) :1691-1697

[10] Lack of Exercise Is a Major Cause of Chronic Diseases [J].

Booth, Frank W. ;

Roberts, Christian K. ;

Laye, Matthew J. .

COMPREHENSIVE PHYSIOLOGY, 2012, 2 (02) :1143-1211

← 1 2 3 4 5 6 7 8 9 10 →